INT167084

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cbl) nucleus (Cbl) ligase activity (Cbl)
cytoplasm (Cbl) signal transducer activity (Cbl)
Cbl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 88 86.64 High High
Arthritis 26 81.12 Quite High
Inflammation 44 71.20 Quite High
cINOD 2 65.92 Quite High
cytokine 53 50.00 Quite Low
Osteoarthritis 5 46.40 Quite Low
chemokine 17 8.24 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
psoriasis 44 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 57 88.24 High High
Rheumatoid Arthritis 89 86.64 High High
Arthritis 16 81.12 Quite High
Targeted Disruption 31 79.56 Quite High
Congenital Anomalies 8 73.00 Quite High
INFLAMMATION 46 71.20 Quite High
Disease 69 67.84 Quite High
Autoimmune Disease 33 66.32 Quite High
Syndrome 1 51.28 Quite High
Craniosynostosis 1 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, Spry2 can potentiate EGFR signaling by binding to c-Cbl and sequestering it away from the EGFR, thus preventing EGFR down regulation and degradation, consequently leading to sustained EGFR activation, and enhanced ERK signaling.
c-Cbl Binding (binding) of
1) Confidence 0.10 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
Whereas sulindac metabolites inhibited phosphorylation of EGFR pY1068, they increased phosphorylation of EGFR pY1045, the docking site where c-Cbl binds, thereby enabling receptor ubiquitination and degradation.
c-Cbl Binding (binds) of
2) Confidence 0.01 Published 2010 Journal Cancer Prev Res (Phila) Section Abstract Doc Link 20332299 Disease Relevance 0.07 Pain Relevance 0.07
IL-27 binds to a receptor composed of WSX-1/TCCR and gp130, the latter of which serves as a common signal transduction receptor for IL-6-related family members.
signal transduction Binding (receptor) of
3) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.09 Pain Relevance 0.32

General Comments

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