INT167096

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 0.89
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Helt) nucleus (Helt) DNA binding (Helt)
Anatomy Link Frequency
neurons 14
spinal 2
GABAergic neurons 2
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 80 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
amygdala 116 99.84 Very High Very High Very High
Anterior cingulate cortex 48 98.76 Very High Very High Very High
gABA 65 97.96 Very High Very High Very High
antagonist 29 90.20 High High
Pyramidal cell 33 85.68 High High
agonist 18 81.00 Quite High
Neurotransmitter 9 59.84 Quite High
Action potential 15 55.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 95.72 Very High Very High Very High
Generalized Anxiety Disorder 2 90.60 High High
Targeted Disruption 62 88.96 High High
Death 78 5.00 Very Low Very Low Very Low
Prion Diseases 36 5.00 Very Low Very Low Very Low
Toxicity 24 5.00 Very Low Very Low Very Low
Convulsion 24 5.00 Very Low Very Low Very Low
Stroke 24 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 18 5.00 Very Low Very Low Very Low
Scrapie 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of GABAergic neurons following tooth pulp stimulation.
Positive_regulation (Activation) of Gene_expression (neurons) of GABAergic in GABAergic neurons associated with nociceptor and gabaergic
1) Confidence 0.05 Published 2010 Journal J. Dent. Res. Section Title Doc Link 20332333 Disease Relevance 0.28 Pain Relevance 0.41
Our results provide direct morphological evidence that a subset of GABAergic neurons in the spinal trigeminal system was activated during tooth pulp stimulation.
Positive_regulation (activated) of Gene_expression (neurons) of GABAergic in spinal associated with gabaergic
2) Confidence 0.05 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20332333 Disease Relevance 0.20 Pain Relevance 0.20
Previously we found that ethanol dose-dependently increased GABAergic transmission in CeA slices by increasing presynaptic vesicular GABA release (Roberto et al., 2003).
Positive_regulation (increased) of Gene_expression (transmission) of GABAergic associated with gaba, gabaergic and amygdala
3) Confidence 0.03 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.54
Ethanol enhancement of GABAergic transmission is absent in CeA neurons of HET mice
Positive_regulation (enhancement) of Gene_expression (transmission) of GABAergic in neurons associated with gabaergic and amygdala
4) Confidence 0.03 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.52
As shown in Fig. 3 E, siRNA knockdown of PrPC in culture phenocopied the PrP-null mice in that a two-fold increase in NMDAR-mediated current decay time was observed relative to untransfected neurons.
Positive_regulation (untransfected) of Gene_expression (untransfected) of neurons in neurons
5) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0.04
All three siRNA constructs were cotransfected into neurons.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of neurons in neurons
6) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 3 E, siRNA knockdown of PrPC in culture phenocopied the PrP-null mice in that a two-fold increase in NMDAR-mediated current decay time was observed relative to untransfected neurons.
Positive_regulation (increase) of Gene_expression (untransfected) of neurons in neurons
7) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0.04
PrP expression was observed to significantly decrease in siRNA-transfected neurons (Fig. 3 D).
Positive_regulation (transfected) of Gene_expression (transfected) of neurons in neurons
8) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0.04
Conversely, the overexpression of Prnp cDNA in neurons obtained from PrP-null mice rescued the WT phenotype (Fig. 3 F), again hinting at a specific regulation of NMDARs by PrPC rather than broad developmental effects associated with deletion of the Prnp gene.
Positive_regulation (overexpression) of Gene_expression (overexpression) of neurons in neurons
9) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.06 Pain Relevance 0.04
Elimination of NR2D subunits via siRNA treatment resulted in a drastic reduction in NMDA current amplitude compared with neurons transfected with only YFP (PrP?
Positive_regulation (transfected) of Gene_expression (transfected) of neurons in neurons
10) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.14 Pain Relevance 0
Activation of GRP receptors enhances spontaneous GABAergic, but not glutamatergic transmission
Neg (not) Positive_regulation (enhances) of Gene_expression (transmission) of GABAergic associated with gabaergic
11) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.67

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