INT167101

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 7.49
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 4
HCC (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 65.96 Quite High
fibrosis 19 7.40 Low Low
Inflammation 8 7.00 Low Low
agonist 19 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Bile 7 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 312 100.00 Very High Very High Very High
Hepatocellular Cancer 253 100.00 Very High Very High Very High
Carcinoma 18 100.00 Very High Very High Very High
Metastasis 34 99.56 Very High Very High Very High
Cancer 208 93.76 High High
Malignant Neoplastic Disease 12 89.44 High High
Cirrhosis 36 89.20 High High
Congenital Anomalies 1 74.12 Quite High
Liver Cancer 34 71.52 Quite High
Disease 17 66.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
serine/threonine residues and is accumulated both in human HCC tissue as well
Positive_regulation (accumulated) of Gene_expression (tissue) of HCC associated with carcinoma
1) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.99 Pain Relevance 0
Lower panel: results from reverse sequencing

Detection of APC protein expression in HCC and liver metastasis

Positive_regulation (sequencing) of Gene_expression (expression) of HCC in liver associated with hepatocellular cancer, familial adenomatous polyposis and metastasis
2) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.41 Pain Relevance 0
Lower panel: results from reverse sequencing

Detection of APC protein expression in HCC and liver metastasis

Positive_regulation (results) of Gene_expression (expression) of HCC in liver associated with hepatocellular cancer, familial adenomatous polyposis and metastasis
3) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.42 Pain Relevance 0
Previous studies focused on epigenetic changes of the APC promoter but did not evaluate the APC protein expression in HCC (Lee et al. 2003; Yang et al. 2003; Esteller et al. 2001; Yu et al. 2002).
Neg (not) Positive_regulation (evaluate) of Gene_expression (expression) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
4) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.81 Pain Relevance 0
Current therapeutic strategies for HCC
Positive_regulation (strategies) of Gene_expression (strategies) of HCC associated with hepatocellular cancer
5) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 1.05 Pain Relevance 0
In this report, we retrospectively studied 152 consecutive patients with advanced HCC resistant to TACE using epirubicin, and all cases were treated with platinum derivatives using transcatheter arterial chemotherapy.
Positive_regulation (advanced) of Gene_expression (resistant) of HCC associated with hepatocellular cancer
6) Confidence 0.03 Published 2010 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 20332675 Disease Relevance 0.81 Pain Relevance 0.07

General Comments

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