INT167112

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 35.12 Quite Low
Inflammation 2 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 68 95.36 Very High Very High Very High
Disease 3 12.88 Low Low
Myocardial Infarction 9 5.00 Very Low Very Low Very Low
Lung Cancer 6 5.00 Very Low Very Low Very Low
Cardiovascular Disease 3 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Asthma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that residue 382 affected CYP1A1 and CYP1A2 specificities with alkoxyresorufins.
Regulation (affected) of CYP1A1
1) Confidence 0.26 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 20335269 Disease Relevance 0 Pain Relevance 0
Regulation of CYP1A1 and CYP1B1 is not fully understood, but transcriptional activation by the AHR constitutes a major mechanism.
Regulation (Regulation) of CYP1A1
2) Confidence 0.20 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.37 Pain Relevance 0
(http://drnelson.utmem.edu/CytochromeP450.htlm) This superfamily is composed of 18 families of genes, four of which—CYP1, CYP2, CYP3 and CYP4—are involved in the metabolism of clinically used drugs.
Regulation (involved) of CYP1
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0

General Comments

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