INT16713

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 53
Total Number 58
Disease Relevance 20.24
Pain Relevance 13.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
SK-N-SH 2
spinal cord 1
nucleus 1
NS20Y 1
dorsal horn 1
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 213 100.00 Very High Very High Very High
Neurotransmitter 71 100.00 Very High Very High Very High
Opioid 9 99.80 Very High Very High Very High
opioid receptor 12 99.52 Very High Very High Very High
spinal dorsal horn 16 99.32 Very High Very High Very High
cva 26 99.02 Very High Very High Very High
Central nervous system 52 98.84 Very High Very High Very High
Hippocampus 134 98.64 Very High Very High Very High
adenocard 7 98.30 Very High Very High Very High
Lasting pain 29 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 450 99.82 Very High Very High Very High
Apoptosis 184 99.78 Very High Very High Very High
Neuroblastoma 55 99.48 Very High Very High Very High
Cold Sores 105 99.16 Very High Very High Very High
Hemorrhage 44 99.02 Very High Very High Very High
Pain 70 98.04 Very High Very High Very High
INFLAMMATION 427 97.96 Very High Very High Very High
Cerebellar Diseases 15 97.24 Very High Very High Very High
Shock 113 97.08 Very High Very High Very High
Manic Depressive Disorder 250 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, our studies indicate that the cAMP binding protein associated with the crude microtubule fraction could be an intracellular target for the action of antidepressant drugs.
cAMP binding protein Binding (associated) of associated with antidepressant
1) Confidence 0.48 Published 1991 Journal Neuropsychopharmacology Section Abstract Doc Link 1848433 Disease Relevance 0 Pain Relevance 0.51
Furthermore, this event involves the binding of CREB to a specific sequence present in the promoter of many cAMP responsive genes.
CREB Binding (binding) of
2) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.16 Pain Relevance 0.11
The rat neurokinin-1 (NK1) receptor gene contains a cyclic adenosine monophosphate (cAMP) response element, and gene transcription may be activated upon binding of phosphorylated cAMP response element binding protein (pCREB).
pCREB Binding (binding) of associated with adenocard
3) Confidence 0.46 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10729626 Disease Relevance 0.07 Pain Relevance 0.12
Possible interactions of other neurotransmitters with CREB is also suggested which needs further studies.
CREB Binding (interactions) of associated with neurotransmitter
4) Confidence 0.45 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.58 Pain Relevance 0.42
Chromatin immunoprecipitation (ChIP) assays show that CREB is recruited to the promoter region upon treatment of NS20Y cells with dibutyryl cAMP.
CREB Binding (recruited) of in NS20Y
5) Confidence 0.43 Published 2006 Journal Gene Section Abstract Doc Link 16935438 Disease Relevance 0.15 Pain Relevance 0.14
The rat neurokinin-1 (NK1) receptor gene contains a cyclic adenosine monophosphate (cAMP) response element, and gene transcription may be activated upon binding of phosphorylated cAMP response element binding protein (pCREB).
phosphorylated cAMP response element binding protein Binding (binding) of associated with adenocard
6) Confidence 0.40 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10729626 Disease Relevance 0.07 Pain Relevance 0.12
significantly lower pCREB expression than Handled CREB rats with the Handled GFP control group falling in between, differing from
CREB Binding (rats) of
7) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.14 Pain Relevance 0.10
likely an underestimate of its value at peak expression of CREB, which occurs at three days after HSV
CREB Binding (occurs) of associated with cold sores
8) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.01 Pain Relevance 0.24
injection is likely an underestimate of its value at peak expression of CREB, which occurs at three days after HSV
CREB Binding (occurs) of associated with cold sores
9) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.41 Pain Relevance 0.06
Therefore, CREB injection per se
CREB Binding (injection) of
10) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.25 Pain Relevance 0.21
In the present study we examined the potential interaction between CREB and BDNF in the spinal dorsal horn.
CREB Spec (examined) Binding (interaction) of in dorsal horn associated with spinal dorsal horn
11) Confidence 0.35 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135945 Disease Relevance 0.19 Pain Relevance 0.30
Furthermore, in line with these studies an interaction between curcumin and dopaminergic receptors, CREB and phospholipase C is suggested, which attenuates the cortical and cerebellar dysfunction in diabetes.
CREB Binding (interaction) of associated with cerebellar diseases and diabetes mellitus
12) Confidence 0.35 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.81 Pain Relevance 0.36
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
CREB Binding (alteration) of associated with dopamine and diabetes mellitus
13) Confidence 0.35 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.81 Pain Relevance 0.45
CRE-binding protein (CREB) binds to these CREs in striatal cell extracts and is phosphorylated on Ser-133 after dopamine stimulation in a D1 dopamine receptor-dependent manner.
CREB Binding (binds) of associated with dopamine and dopamine receptor
14) Confidence 0.34 Published 1995 Journal Neuron Section Abstract Doc Link 7718243 Disease Relevance 0 Pain Relevance 0.31
Specific inhibitors of each kinase significantly attenuated the ligation-associated CREB phosphorylation when compared to saline-treated animals.
CREB Binding (ligation-associated) of
15) Confidence 0.34 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.16 Pain Relevance 0.44
Combined application of the ERK1/2 and CaMKII inhibitors also attenuated the ligation-associated CREB activation but not to a greater extent than either inhibitor alone.
CREB Binding (ligation-associated) of
16) Confidence 0.34 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.21 Pain Relevance 0.46
In the present investigation the generation of unique functional properties of curcumin via dopamine D1, D2 receptors, CREB and phospholoipase C interactions may yield a better understanding of behaviour and CNS disorders induced by diabetes.


CREB Binding (interactions) of associated with dopamine and diabetes mellitus
17) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 1.21 Pain Relevance 0.13
The effect of curcumin in interacting with the dopaminergic receptor and CREB in STZ-induced diabetes proves its potential in managing CNS disorders in diabetes.
CREB Binding (interacting) of associated with diabetes mellitus
18) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.54 Pain Relevance 0.39
In addition, the production of ppN/OFQ mRNA is regulated by histone acetylation, also through CREB, as the histone deacetylase (HDAC) inhibitor trichostatin A increases both CREB binding to the promoter and ppN/OFQ mRNA expression.
CREB Binding (binding) of
19) Confidence 0.33 Published 2006 Journal Gene Section Abstract Doc Link 16935438 Disease Relevance 0.16 Pain Relevance 0.12
Furthermore, the cross-competition studies revealed that the AP-1 proteins, rather than CREB, actively bind to ENKCRE-2 DNA domain.
CREB Binding (bind) of
20) Confidence 0.33 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.55

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