INT167145

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.40
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
muscle 2
brain 2
immune system 2
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 9 100.00 Very High Very High Very High
analgesia 2 100.00 Very High Very High Very High
Pain 10 99.66 Very High Very High Very High
Nerve growth factor 66 99.52 Very High Very High Very High
Fibrositis 2 99.08 Very High Very High Very High
Inflammation 32 96.96 Very High Very High Very High
Analgesic 2 83.92 Quite High
unmyelinated 1 82.12 Quite High
substance P 6 72.20 Quite High
Central nervous system 10 65.96 Quite High
Disease Link Frequency Relevance Heat
Infection 63 99.12 Very High Very High Very High
Fibromyalgia 2 99.08 Very High Very High Very High
INFLAMMATION 41 96.96 Very High Very High Very High
Congenital Anomalies 1 95.12 Very High Very High Very High
Pain 6 93.76 High High
Syndrome 2 90.64 High High
Viral Infection 17 90.60 High High
Asthma 65 89.36 High High
Disease 28 88.88 High High
Cytomegalovirus Infection 56 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the increase in NT-3 protein was significant in the gastrocnemius muscle but not in the soleus muscle, suggesting that exercise can preferentially target NT-3 synthesis in specific muscle types.
Regulation (target) of Gene_expression (synthesis) of NT-3 in muscle
1) Confidence 0.54 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.05 Pain Relevance 0
Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain.
Regulation (alters) of Gene_expression (synthesis) of neurotrophin-3 associated with pain, fibrositis and analgesia
2) Confidence 0.27 Published 2010 Journal Phys Ther Section Title Doc Link 20338916 Disease Relevance 0.37 Pain Relevance 0.70
The infection of neonatal brain was also associated with altered expression of the neurotrophins BDNF and NT3, which are essential for normal development of brain [29], [30].
Regulation (altered) of Gene_expression (expression) of NT3 in brain associated with neurotrophin 3 and infection
3) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.06 Pain Relevance 0.19
Further, this study broadens the context in which we should consider the consequences of dysregulated neurotrophin expression.


Regulation (dysregulated) of Gene_expression (expression) of neurotrophin
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.27 Pain Relevance 0.09
In the former class, a purine-hypoxanthine derivative, leteprinim (Neotrofin), has been shown to elevate neurotrophin levels (including NGF) in animals, and caused increases in acetylcholinesterase labeling in lesioned rats [106].
Regulation (elevate) of Gene_expression (levels) of neurotrophin associated with nerve growth factor
5) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.50 Pain Relevance 0.21
On the basis of these observations, we postulate that changes of neurotrophin expression in the respiratory tract may coordinate a variety of interactions between sensory afferent nerves and multiple components of the immune system and inflammatory pathways, thereby generating a pathophysiological link between early-life viral infections and childhood asthma.


Regulation (changes) of Gene_expression (expression) of neurotrophin in immune system associated with asthma, inflammation and viral infection
6) Confidence 0.06 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 1.14 Pain Relevance 0.46

General Comments

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