INT16715

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.60
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
pituitary 2
brain 2
intestine 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
Opioid 7 99.76 Very High Very High Very High
Morphine 4 98.96 Very High Very High Very High
narcan 9 98.80 Very High Very High Very High
Pain 2 92.32 High High
antagonist 4 89.24 High High
Inflammation 9 79.60 Quite High
Central nervous system 1 79.00 Quite High
agonist 3 78.36 Quite High
Analgesic 3 76.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 95.44 Very High Very High Very High
Pain 3 92.32 High High
Inflammatory Pain 1 49.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased abundance of opioid receptor heteromers after chronic morphine administration.
Positive_regulation (Increased) of Transcription (abundance) of opioid receptor associated with opioid receptor and morphine
1) Confidence 0.66 Published 2010 Journal Sci Signal Section Title Doc Link 20647592 Disease Relevance 0.08 Pain Relevance 0.50
Furthermore, the inability of chronic Li treatment to modify either the content or basal release of beta-endorphin in various brain regions suggests that this antagonism is mediated directly at the level of the opioid receptor and/or its transducer systems.
Positive_regulation (mediated) of Transcription (level) of opioid receptor in brain associated with opioid receptor
2) Confidence 0.30 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1848627 Disease Relevance 0 Pain Relevance 0.75
It is also involved in the enhanced antitransit and antiexudative effects produced by opioids and in the up-regulation of the mu-opioid receptor gene transcription observed in the inflamed intestine.
Positive_regulation (up-regulation) of Transcription (transcription) of opioid receptor in intestine associated with opioid receptor and opioid
3) Confidence 0.06 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691937 Disease Relevance 0.52 Pain Relevance 1.12
The difference observed between naloxone and nalmefene on prolactin--LH pulse synchrony is probably due to differential opioid receptor activity at the pituitary and hypothalamic level.
Spec (probably) Positive_regulation (due) of Transcription (activity) of opioid receptor in pituitary associated with narcan and opioid receptor
4) Confidence 0.01 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8300813 Disease Relevance 0 Pain Relevance 0.37

General Comments

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