INT167162

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Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.52
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ING1) cell cycle (ING1)
Anatomy Link Frequency
neutrophils 3
ING1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 40 98.72 Very High Very High Very High
Inflammatory stimuli 4 92.48 High High
Analgesic 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 4 99.52 Very High Very High Very High
INFLAMMATION 4 92.16 High High
Stress 4 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, treatment with SB203580, the p38 MAPK inhibitor, also mitigated fMLP-induced superoxide anion generation and p38 MAPK and p47(phox) phosphorylation as well as apoptosis in a concentration-dependent fashion in neutrophils.
Phosphorylation (phosphorylation) of p47 in neutrophils associated with apoptosis
1) Confidence 0.64 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.10 Pain Relevance 0.39
Here, we show that treatment with S(+)-ketamine or R(-)-ketamine at different concentrations (50, 100, 200, 400 microM) reduced fMLP-induced superoxide anion generation and p47(phox) phosphorylation in neutrophils in a concentration-dependent manner (y = -0.093x + 93.35 for S(+)-ketamine and y = -0.0982x + 95.603 for R(-)-ketamine, respectively).
Phosphorylation (phosphorylation) of p47 in neutrophils associated with ketamine
2) Confidence 0.64 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.15 Pain Relevance 0.42
Therefore, ketamine racemes inhibited fMLP-induced superoxide anion generation and p47(phox) phosphorylation by modulating fMLP-mediated p38 MAPK activation in neutrophils.
Phosphorylation (phosphorylation) of p47 in neutrophils associated with ketamine
3) Confidence 0.64 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.09 Pain Relevance 0.36
The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47(phox), one subunit of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
Phosphorylation (phosphorylation) of p47
4) Confidence 0.64 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.18 Pain Relevance 0.24

General Comments

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