INT167173

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ccl2, Ccr2) cytosol (Ccr2) extracellular space (Ccl2)
aging (Ccl2) extracellular region (Ccl2) plasma membrane (Ccr2)
Anatomy Link Frequency
neurons 1
Ccl2 (Rattus norvegicus)
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 36 91.28 High High
antinociception 4 90.00 High High
chemokine 7 85.84 High High
Hyperalgesia 18 83.76 Quite High
antagonist 23 68.80 Quite High
Spinal cord 36 64.08 Quite High
analgesia 20 61.92 Quite High
Pain 5 60.84 Quite High
Neuropathic pain 23 51.08 Quite High
Action potential 9 39.52 Quite Low
Disease Link Frequency Relevance Heat
Nociception 11 99.44 Very High Very High Very High
Injury 40 93.84 High High
Hyperalgesia 26 83.76 Quite High
Ganglion Cysts 2 75.00 Quite High
Pain 7 60.84 Quite High
Neuropathic Pain 44 51.08 Quite High
Hypersensitivity 2 32.32 Quite Low
Nervous System Injury 6 27.44 Quite Low
INFLAMMATION 2 17.32 Low Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whole-cell patch-clamp recordings revealed that CCL2, a ligand for CCR2 receptor, depolarized nociceptive DRG neurons from rats of the all three models.
CCL2 Binding (ligand) of CCR2 receptor in neurons associated with nociception
1) Confidence 0.30 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.90 Pain Relevance 0.41
In vitro effects of CCL2, which preferentially binds to CCR2 receptor [21,32], were blocked by AZ889 suggesting a specific CCR2 excitatory mechanism.
CCL2 Binding (binds) of CCR2 receptor
2) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.26 Pain Relevance 0.58

General Comments

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