INT167174

Context Info Confidence 0.06 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 3.05 Pain Relevance 4.25

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1) cytoplasm (FSCN1)

Anatomy Link Frequency neuronal 2 nerve 2 neurons 2 IB4 2 dorsal horn 2 FSCN1 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal nerve ligature 176 100.00 allodynia 120 100.00 Eae 8 100.00 Dorsal horn 54 99.20 dorsal root ganglion 33 98.76 Calcitonin gene-related peptide 15 89.52 substance P 4 77.52 chemokine 8 75.84 withdrawal 23 70.16 Thalamus 89 50.00

Disease Link Frequency Relevance Heat Neuropathic Pain 277 100.00 Injury 51 100.00 Nervous System Injury 71 99.00 Ganglion Cysts 35 98.76 Weight Gain 2 94.48 Nociception 57 93.96 Overdose 1 16.80 Pain 64 5.00 Hyperalgesia 9 5.00 INFLAMMATION 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Besides its effect on the SNL-induced ipsilateral mechanic allodynia, c-fos ASO significantly inhibited SNL-induced Fos protein expression in the ipsilateral dorsal horn.

Negative_regulation (inhibited) of Gene_expression (expression) of SNL-induced in dorsal horn associated with allodynia, spinal nerve ligature and dorsal horn

1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.95

Inhibition of ASO on SNL-induced Fos expression occured right after the nerve injury (at 2 h after SNL).

Negative_regulation (Inhibition) of Gene_expression (expression) of SNL-induced in nerve associated with nervous system injury and spinal nerve ligature

2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.32 Pain Relevance 1.04

C-fos ASO treatment suppressed SNL-induced neuronal and astrocytic activations in different manners

Negative_regulation (suppressed) of Gene_expression (neuronal) of SNL-induced in neuronal associated with spinal nerve ligature

3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.85

Two weeks after SNL, a marked decrease of IB4 binding (both the cell number and the intensity) was observed in ipsilateral L5 DRGs (Figure 5D), which is similar to that shown by a previous study [16].

Negative_regulation (decrease) of Gene_expression (weeks) of SNL in IB4

4) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.63 Pain Relevance 0.61

Furthermore, CCL2 significantly lowered current threshold only in CCD neurons but not in CCI or SNL neurons.

Negative_regulation (lowered) of Neg (not) Gene_expression (neurons) of SNL in neurons associated with eae

5) Confidence 0.03 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.94 Pain Relevance 0.43

Development of mechanical allodynia in SNL rats

Negative_regulation (Development) of Gene_expression (rats) of SNL associated with allodynia

6) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.36 Pain Relevance 0.37

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