INT167174

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.05
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
neuronal 2
nerve 2
neurons 2
IB4 2
dorsal horn 2
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 176 100.00 Very High Very High Very High
allodynia 120 100.00 Very High Very High Very High
Eae 8 100.00 Very High Very High Very High
Dorsal horn 54 99.20 Very High Very High Very High
dorsal root ganglion 33 98.76 Very High Very High Very High
Calcitonin gene-related peptide 15 89.52 High High
substance P 4 77.52 Quite High
chemokine 8 75.84 Quite High
withdrawal 23 70.16 Quite High
Thalamus 89 50.00 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 277 100.00 Very High Very High Very High
Injury 51 100.00 Very High Very High Very High
Nervous System Injury 71 99.00 Very High Very High Very High
Ganglion Cysts 35 98.76 Very High Very High Very High
Weight Gain 2 94.48 High High
Nociception 57 93.96 High High
Overdose 1 16.80 Low Low
Pain 64 5.00 Very Low Very Low Very Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides its effect on the SNL-induced ipsilateral mechanic allodynia, c-fos ASO significantly inhibited SNL-induced Fos protein expression in the ipsilateral dorsal horn.
Negative_regulation (inhibited) of Gene_expression (expression) of SNL-induced in dorsal horn associated with allodynia, spinal nerve ligature and dorsal horn
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.95
Inhibition of ASO on SNL-induced Fos expression occured right after the nerve injury (at 2 h after SNL).
Negative_regulation (Inhibition) of Gene_expression (expression) of SNL-induced in nerve associated with nervous system injury and spinal nerve ligature
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.32 Pain Relevance 1.04
C-fos ASO treatment suppressed SNL-induced neuronal and astrocytic activations in different manners
Negative_regulation (suppressed) of Gene_expression (neuronal) of SNL-induced in neuronal associated with spinal nerve ligature
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.85
Two weeks after SNL, a marked decrease of IB4 binding (both the cell number and the intensity) was observed in ipsilateral L5 DRGs (Figure 5D), which is similar to that shown by a previous study [16].
Negative_regulation (decrease) of Gene_expression (weeks) of SNL in IB4
4) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.63 Pain Relevance 0.61
Furthermore, CCL2 significantly lowered current threshold only in CCD neurons but not in CCI or SNL neurons.
Negative_regulation (lowered) of Neg (not) Gene_expression (neurons) of SNL in neurons associated with eae
5) Confidence 0.03 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.94 Pain Relevance 0.43
Development of mechanical allodynia in SNL rats
Negative_regulation (Development) of Gene_expression (rats) of SNL associated with allodynia
6) Confidence 0.02 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.36 Pain Relevance 0.37

General Comments

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