INT167174
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Besides its effect on the SNL-induced ipsilateral mechanic allodynia, c-fos ASO significantly inhibited SNL-induced Fos protein expression in the ipsilateral dorsal horn. | |||||||||||||||
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Inhibition of ASO on SNL-induced Fos expression occured right after the nerve injury (at 2 h after SNL). | |||||||||||||||
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C-fos ASO treatment suppressed SNL-induced neuronal and astrocytic activations in different manners | |||||||||||||||
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Two weeks after SNL, a marked decrease of IB4 binding (both the cell number and the intensity) was observed in ipsilateral L5 DRGs (Figure 5D), which is similar to that shown by a previous study [16]. | |||||||||||||||
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Furthermore, CCL2 significantly lowered current threshold only in CCD neurons but not in CCI or SNL neurons. | |||||||||||||||
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Development of mechanical allodynia in SNL rats | |||||||||||||||
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General Comments
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