INT167175

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatocytes 2
sciatic nerves 1
Cdc2b (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 99.36 Very High Very High Very High
Spinal cord 1 83.96 Quite High
allodynia 3 77.48 Quite High
Eae 4 76.04 Quite High
Peripheral nerve injury 2 75.00 Quite High
Neuropathic pain 1 74.96 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 82.00 Quite High
Neuropathic Pain 5 77.48 Quite High
Injury 6 76.04 Quite High
Nervous System Injury 2 75.00 Quite High
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, in sections of injured sciatic nerves, we analyzed the expression of Cdc2 and GAP-43 proteins that are both up-regulated during peripheral regenerative processes.
Positive_regulation (up-regulated) of Cdc2 in sciatic nerves associated with sciatic nerve
1) Confidence 0.47 Published 2010 Journal Neuroscience Section Abstract Doc Link 20347016 Disease Relevance 0.70 Pain Relevance 0.66
A persistent EGF supplementation in vitro was able only partially rescue the effect of Erk1/2 downregulation in c-Met depleted hepatocytes and restore to some extent the levels of cdc2, Aurora A and B, and Mad2.
Positive_regulation (restore) of cdc2 in hepatocytes
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
Continuous EGF stimulation for 72 hr was able to increase Erk1/2 phosphorylation and restore both DNA synthesis and protein levels of cdc2, Aurora A, Aurora B, and Mad1and 2 albeit to a considerably lesser degree as compared to control hepatocytes, again underscoring a key contribution of c-Met to maintaining an adequate levels of cell proliferation.


Positive_regulation (restore) of cdc2 in hepatocytes
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0

General Comments

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