INT167176

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.56
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerves 1
Cdc2b (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 99.36 Very High Very High Very High
Inflammatory response 5 98.22 Very High Very High Very High
Spinal cord 1 83.96 Quite High
allodynia 3 77.48 Quite High
Eae 4 76.04 Quite High
Peripheral nerve injury 2 75.00 Quite High
Neuropathic pain 1 74.96 Quite High
cytokine 7 60.76 Quite High
Inflammation 14 60.36 Quite High
Thoracotomy 6 49.68 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 19 98.02 Very High Very High Very High
Apoptosis 16 97.80 Very High Very High Very High
Adenocarcinoma 1 88.60 High High
Colon Cancer 1 87.16 High High
Neuropathic Pain 5 77.48 Quite High
Injury 6 76.04 Quite High
Nervous System Injury 2 75.00 Quite High
Adhesions 2 65.04 Quite High
Targeted Disruption 37 64.12 Quite High
Papillomavirus Infection 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, in sections of injured sciatic nerves, we analyzed the expression of Cdc2 and GAP-43 proteins that are both up-regulated during peripheral regenerative processes.
Regulation (regulated) of Cdc2 in sciatic nerves associated with sciatic nerve
1) Confidence 0.45 Published 2010 Journal Neuroscience Section Abstract Doc Link 20347016 Disease Relevance 0.70 Pain Relevance 0.66
Finally, at 7 days, the top networks are focused on immunomodulation and inflammatory responses (up-regulation of NPPA/ANP and Brca1 - Figure 5A), and continued cell proliferation (up-regulation of Birc5, Foxm1, Cdc2, Ccnb1 and Ccna2 - Figure 5B).


Regulation (regulation) of Cdc2 associated with inflammatory response
2) Confidence 0.14 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.42 Pain Relevance 0.21
In summary, we identified important genes that are altered at the transcriptional level by E6 in our model, in particular the uncoupling of cell cycle regulation (cdc2, cyclin B, cdk2 and cyclin E), down-regulation of pro-apoptotic genes (Fas) and up-regulation of anti-apoptotic genes (Birc5).
Regulation (regulation) of cdc2 associated with apoptosis
3) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.43 Pain Relevance 0

General Comments

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