INT167178

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.40
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatocytes 3
sciatic nerves 1
Cdc2b (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 99.64 Very High Very High Very High
Spinal cord 1 84.52 Quite High
allodynia 3 78.04 Quite High
Eae 7 76.60 Quite High
Peripheral nerve injury 2 75.00 Quite High
Neuropathic pain 1 71.20 Quite High
headache 1 47.92 Quite Low
Analgesic 1 45.84 Quite Low
Inflammation 2 16.80 Low Low
anesthesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 113 98.80 Very High Very High Very High
Targeted Disruption 54 98.76 Very High Very High Very High
Leukemia 1 98.64 Very High Very High Very High
Hepatocellular Cancer 16 97.88 Very High Very High Very High
Cancer 32 89.36 High High
Retinoblastoma 1 84.64 Quite High
Neurodegenerative Disease 9 79.04 Quite High
Neuropathic Pain 5 78.04 Quite High
Injury 10 76.60 Quite High
Nervous System Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, in sections of injured sciatic nerves, we analyzed the expression of Cdc2 and GAP-43 proteins that are both up-regulated during peripheral regenerative processes.
Spec (analyzed) Gene_expression (expression) of Cdc2 in sciatic nerves associated with sciatic nerve
1) Confidence 0.78 Published 2010 Journal Neuroscience Section Abstract Doc Link 20347016 Disease Relevance 0.70 Pain Relevance 0.66
Continuous EGF stimulation for 72 hr was able to increase Erk1/2 phosphorylation and restore both DNA synthesis and protein levels of cdc2, Aurora A, Aurora B, and Mad1and 2 albeit to a considerably lesser degree as compared to control hepatocytes, again underscoring a key contribution of c-Met to maintaining an adequate levels of cell proliferation.


Gene_expression (synthesis) of cdc2 in hepatocytes
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
A persistent EGF supplementation in vitro was able only partially rescue the effect of Erk1/2 downregulation in c-Met depleted hepatocytes and restore to some extent the levels of cdc2, Aurora A and B, and Mad2.
Gene_expression (levels) of cdc2 in hepatocytes
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
Continuous EGF stimulation for 72 hr was able to increase Erk1/2 phosphorylation and restore both DNA synthesis and protein levels of cdc2, Aurora A, Aurora B, and Mad1and 2 albeit to a considerably lesser degree as compared to control hepatocytes, again underscoring a key contribution of c-Met to maintaining an adequate levels of cell proliferation.


Gene_expression (levels) of cdc2 in hepatocytes
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
The results showed that cdc2 and Aurora B expression were similarly repressed at 36–42 hr concordant with the lack of ERK1/2 activation (Figure 4C).
Gene_expression (expression) of cdc2
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.10 Pain Relevance 0
cyclin B, Cdc2, Cdc25B, Polo-like kinase, Myt1/Wee1, and p27Kip1,
Gene_expression (cyclin B) of Cdc2
6) Confidence 0.23 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 0.37 Pain Relevance 0
Down regulated expression of cdc2 and COX-2 contributed to the apoptosis and cell cycle arrest in HepG2 cells [13].
Gene_expression (expression) of cdc2 associated with apoptosis
7) Confidence 0.21 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.70 Pain Relevance 0
Similarly, neither estrogen nor sFasL significantly altered the expression of Cyclin-dependent Kinase-1 (cdk1/cdc2) relative to control cultures, suggesting that that interactions between estrogen and Fas activation were not specifically related to cell cycle.


Gene_expression (expression) of cdc2
8) Confidence 0.08 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.29 Pain Relevance 0

General Comments

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