INT167194

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FPR1, ITGAM) endosome (FPR1) signal transduction (FPR1)
cell adhesion (ITGAM) signal transducer activity (FPR1)
Anatomy Link Frequency
neutrophils 2
FPR1 (Homo sapiens)
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 94.72 High High
lidocaine 2 89.80 High High
Potency 2 85.24 High High
local anesthetic 4 62.32 Quite High
Disease Link Frequency Relevance Heat
Adhesions 8 95.36 Very High Very High Very High
INFLAMMATION 6 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
fMLP Neg (no) Positive_regulation (induced) of Gene_expression (expression) of CD11b in neutrophils
1) Confidence 0.52 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.36 Pain Relevance 0.19
In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).
fMLP Positive_regulation (induced) of Gene_expression (expression) of CD11b
2) Confidence 0.52 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.43 Pain Relevance 0.34

General Comments

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