INT167197

Context Info Confidence 0.46 First Reported 2009 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.76 Pain Relevance 0.19

extracellular space (Prom1) plasma membrane (Prom1) cilium (Prom1)

Anatomy Link Frequency precursor cells 1 Prom1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 9 99.34 anesthesia 4 70.56 imagery 44 70.00 alcohol 1 25.76 neurotrophin 3 8 5.00 long-term potentiation 1 5.00 cerebral cortex 1 5.00 ketamine 1 5.00 Glutamate 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Cancer 157 99.08 Infection 49 79.64 Cytomegalovirus Infection 56 79.24 Viral Infection 13 63.04 Neurodegenerative Disease 9 50.00 Calcification 1 39.28 Hydrocephalus 1 38.16 Blindness 1 36.92 Intellectual Impairment 3 36.48 Deafness 1 35.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also found that a small population of CD133-negative cells in the tumors bound injected AC133.1-Alexa488.

Positive_regulation (population) of CD133 associated with cancer

1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.24 Pain Relevance 0

Our results showed that there was an increase of Sca-1(+) and prominin-1(+) cells in the lineage(-) fraction over the unpurified BM.

Positive_regulation (increase) of prominin-1

2) Confidence 0.45 Published 2010 Journal Cell Transplant Section Abstract Doc Link 20350359 Disease Relevance 0 Pain Relevance 0.07

These studies indicate that human CNS precursor cells expressing high levels of the surface antigen CD133 (CD133+/hi), with little or no CD24 (CD24?

Positive_regulation (levels) of CD133 in precursor cells associated with central nervous system

3) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.46 Pain Relevance 0.09

Cells expressing higher levels of CD133 than the immunoglobulin G (IgG) controls were considered positive.

Positive_regulation (levels) of CD133

4) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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