INT167203

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 25
Total Number 30
Disease Relevance 20.09
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
Anatomy Link Frequency
PRP 1
blood 1
cerebral cortex 1
striatum 1
dura mater 1
PRNP (Homo sapiens)
PRNP - V210I (1) PRNP - P102L (1)
Pain Link Frequency Relevance Heat
Pain 65 100.00 Very High Very High Very High
depression 10 100.00 Very High Very High Very High
iatrogenic 54 99.98 Very High Very High Very High
Hippocampus 21 97.32 Very High Very High Very High
Substantia nigra 8 96.80 Very High Very High Very High
Thalamus 17 96.08 Very High Very High Very High
cerebral cortex 18 95.28 Very High Very High Very High
Central nervous system 28 73.36 Quite High
interstitial cystitis 1 70.24 Quite High
cva 3 64.00 Quite High
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 878 100.00 Very High Very High Very High
Kuru 543 100.00 Very High Very High Very High
Scrapie 160 100.00 Very High Very High Very High
Pain 45 100.00 Very High Very High Very High
Sleep Disorders 23 100.00 Very High Very High Very High
Fatigue 8 100.00 Very High Very High Very High
Depression 6 100.00 Very High Very High Very High
Disease 604 99.96 Very High Very High Very High
Targeted Disruption 229 99.52 Very High Very High Very High
Prion Diseases 239 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following microsatellite and genealogical studies, 40 new patients were identified from the ‘W’ kindred, likely to be associated with the P102L PRNP mutation.
PRNP (P102L) Spec (likely) Binding (associated) of
1) Confidence 0.48 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.06 Pain Relevance 0
It is of interest that iatrogenic CJD associated with peripheral inoculation with human prions (treatment with contaminated pituitary growth hormone or gonadotrophin) typically presents with ataxia, in sharp contrast to direct CNS exposure by contaminated neurosurgical instruments and dura mater grafting, where the phenotype is generally of classical CJD.
CJD Binding (associated) of in dura mater associated with iatrogenic, creutzfeldt jakob disease and ataxia
2) Confidence 0.42 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 1.45 Pain Relevance 0.05
To date, approximately 170 vCJD patients have been recognized in the UK and approximately 30 cases from other countries including France, Italy, The Netherlands, Ireland, Spain, Canada, Japan and the USA.
vCJD Binding (recognized) of
3) Confidence 0.42 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 0.77 Pain Relevance 0
Methionine/valine polymorphism on codon 129 of this gene is found to be associated with CJD.
CJD Binding (associated) of associated with creutzfeldt jakob disease
4) Confidence 0.38 Published 2008 Journal Cases J Section Body Doc Link PMC2547099 Disease Relevance 0.63 Pain Relevance 0.04
Although the number of patients in our study was necessarily small, there was no evidence of association of kuru with PRNP haplotype, HLA DQ7, ApoE or PRND alleles (Collinge et al. 2006).
PRNP Neg (no) Binding (association) of associated with kuru
5) Confidence 0.37 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 0.80 Pain Relevance 0
PrP might compete for a common hypothetical receptor or ligand LPrP that transduces neuroprotective signals when bound to PrPC but not when bound to Dpl or ?
PrPC Spec (might) Binding (bound) of
6) Confidence 0.37 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.39 Pain Relevance 0.07
It has long been known that the interaction between prion protein, scrapie isoform (PrPSc) and prion protein, normal cellular isoform (PrPc) occurs most efficiently when the proteins have an identical primary structure (Palmer et al., 1991); therefore, prion replication may occur more rapidly and clinical onset earlier in 129MM individuals.
PrPc Binding (interaction) of associated with scrapie
7) Confidence 0.37 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.56 Pain Relevance 0.03
Difficulties associated with modelling human prion disease in human PrP expressing transgenic mice
PrP Binding (associated) of associated with targeted disruption and creutzfeldt jakob disease
8) Confidence 0.33 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 1.25 Pain Relevance 0
PrP might compete for a common hypothetical receptor or ligand LPrP that transduces neuroprotective signals when bound to PrPC but not when bound to Dpl or ?
PrP Neg (not) Spec (might) Binding (compete) of
9) Confidence 0.33 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.36 Pain Relevance 0.06
It has long been known that the interaction between prion protein, scrapie isoform (PrPSc) and prion protein, normal cellular isoform (PrPc) occurs most efficiently when the proteins have an identical primary structure (Palmer et al., 1991); therefore, prion replication may occur more rapidly and clinical onset earlier in 129MM individuals.
prion protein Binding (interaction) of associated with scrapie
10) Confidence 0.32 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.56 Pain Relevance 0.03
It has long been known that the interaction between prion protein, scrapie isoform (PrPSc) and prion protein, normal cellular isoform (PrPc) occurs most efficiently when the proteins have an identical primary structure (Palmer et al., 1991); therefore, prion replication may occur more rapidly and clinical onset earlier in 129MM individuals.
prion protein Binding (interaction) of associated with scrapie
11) Confidence 0.32 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.56 Pain Relevance 0.03
Since 1996, a new human prion disease, variant Creutzfeldt–Jakob disease (vCJD), has been recognized in the UK and experimental studies, involving both molecular and biological strain-typing methods, have confirmed that this is caused by the same prion strain as that causing BSE in cattle (Collinge et al. 1996b; Bruce et al. 1997; Hill et al. 1997a; Asante et al. 2002).
vCJD Binding (recognized) of associated with creutzfeldt jakob disease, prion diseases, sprains and strains and disease
12) Confidence 0.31 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 1.09 Pain Relevance 0
Familial CJD is associated with a relatively early onset (40–50 years of age) and a prolonged course (22–24 months).
CJD Binding (associated) of associated with creutzfeldt jakob disease
13) Confidence 0.28 Published 2008 Journal Cases J Section Body Doc Link PMC2547099 Disease Relevance 1.03 Pain Relevance 0.07
The number of platelets (PLTs) was determined on whole blood and on PRP under a microscope with a haemocytometer after 1/100 dilution with ammonium oxalate (Unopette1, Becton Dickinson, Milan, Italy).
PRP Spec (determined) Binding (blood) of in blood
14) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2954989 Disease Relevance 0 Pain Relevance 0
On the other hand, MM2 sCJD was characterized by a stronger PrPSc accumulation in the septum, lateral habenular nuclei, and hypothalamus, with only sparse labeling in the cerebral cortex and striatum.
sCJD Binding (characterized) of in striatum associated with cerebral cortex
15) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 0.32 Pain Relevance 0.33
However, based on PrPSc accumulation assessed by Western blot and/or spongiform changes assessed by histopathology, 40%–50% of mice surviving for more than 250 d after inoculation with MM1/MV1 sCJD, MM2 sCJD, and V210I gCJD showed unequivocal signs of prion infection and were thus considered infected (unpublished data).
V210I gCJD (V210I) Binding (inoculation) of associated with infection
16) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 1.10 Pain Relevance 0
However, based on PrPSc accumulation assessed by Western blot and/or spongiform changes assessed by histopathology, 40%–50% of mice surviving for more than 250 d after inoculation with MM1/MV1 sCJD, MM2 sCJD, and V210I gCJD showed unequivocal signs of prion infection and were thus considered infected (unpublished data).
sCJD Binding (inoculation) of associated with infection
17) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 1.09 Pain Relevance 0
Voles inoculated with MM2 sCJD succumbed to disease with longer survival times (Table 1), while MV2 and VV2 sCJD did not induce disease up to 500 d after inoculation.
sCJD Binding (inoculated) of associated with disease
18) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 0.64 Pain Relevance 0
However, based on PrPSc accumulation assessed by Western blot and/or spongiform changes assessed by histopathology, 40%–50% of mice surviving for more than 250 d after inoculation with MM1/MV1 sCJD, MM2 sCJD, and V210I gCJD showed unequivocal signs of prion infection and were thus considered infected (unpublished data).
MV1 sCJD Binding (inoculation) of associated with infection
19) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 1.09 Pain Relevance 0
PRP seems to be an ideal vehicle to provide numerous growth factors, and it has been widely experimented on worldwide in numerous fields because of its potential to facilitate the healing process.
PRP Binding (experimented) of
20) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2954989 Disease Relevance 0 Pain Relevance 0

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