INT167206

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.11
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)
Anatomy Link Frequency
T lymphocytes 2
Casp8 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 4 92.04 High High
agonist 2 91.44 High High
cytokine 22 86.56 High High
antagonist 2 85.36 High High
Inflammation 8 50.00 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 78 99.60 Very High Very High Very High
Apoptosis 90 99.36 Very High Very High Very High
Death 31 88.80 High High
Cancer 121 82.92 Quite High
Melanoma 63 82.60 Quite High
Lung Cancer 3 79.44 Quite High
INFLAMMATION 9 77.68 Quite High
Sprains And Strains 2 70.32 Quite High
Toxicity 5 60.56 Quite High
American Trypanosomiasis 12 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with darbufelone also induced apoptosis by activating caspase-3 and caspase-8.
Positive_regulation (induced) of Positive_regulation (activating) of caspase-8
1) Confidence 0.49 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0
Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h (Figure 2B) and 48 h (data not shown), as compared to the respective controls.
Positive_regulation (elevated) of Positive_regulation (activities) of caspase-8
2) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.45 Pain Relevance 0
Rimcazole did not upregulate TRAIL-R1 or TRAIL-R2 expression (data not shown), but augmented the activation of initiator caspase-8 and initiator caspase-9 upon anti-MCSP:TRAIL treatment (Additional file 3, Figure S2A and B, respectively).
Neg (not) Positive_regulation (augmented) of Positive_regulation (activation) of caspase-8
3) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.62 Pain Relevance 0.18
Moreover, CD4+ and CD8+ T lymphocytes are affected by Fas-induced apoptosis, since activated T lymphocytes increase Fas, FasL expression, and caspase-8 activation in acute infection [51],[68].
Positive_regulation (increase) of Positive_regulation (activation) of caspase-8 in T lymphocytes associated with apoptosis and infection
4) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.88 Pain Relevance 0.08

General Comments

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