INT16721

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 56
Total Number 89
Disease Relevance 44.44
Pain Relevance 22.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
lung 22
brain 9
epithelial cells 6
liver 4
hepatocytes 2
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1795 99.88 Very High Very High Very High
opioid receptor 3 99.52 Very High Very High Very High
Inflammation 893 99.38 Very High Very High Very High
Paracetamol 75 99.20 Very High Very High Very High
adenocard 22 99.16 Very High Very High Very High
tail-flick 26 99.00 Very High Very High Very High
Arthritis 55 98.48 Very High Very High Very High
cytokine 278 98.22 Very High Very High Very High
agonist 11 98.00 Very High Very High Very High
diclofenac 88 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acatalasemia 96 100.00 Very High Very High Very High
Fibrosis 1411 99.88 Very High Very High Very High
Lung Injury 100 99.84 Very High Very High Very High
Pulmonary Fibrosis 928 99.60 Very High Very High Very High
Stress 892 99.44 Very High Very High Very High
INFLAMMATION 810 99.38 Very High Very High Very High
Pneumonia 128 99.08 Very High Very High Very High
Arthritis 60 98.48 Very High Very High Very High
Injury 183 98.08 Very High Very High Very High
Lung Cancer 35 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the reinstatement of place preference was not modified by catalase inhibition.
Negative_regulation (inhibition) of catalase
1) Confidence 0.59 Published 2008 Journal Physiol. Behav. Section Abstract Doc Link 18155096 Disease Relevance 0.08 Pain Relevance 0.26
The same 3-AT treatment, however, did not abolish hepatoprotection in CFB-pretreated mice, despite the marked inhibition of hepatic catalase activity.
Negative_regulation (inhibition) of catalase
2) Confidence 0.59 Published 2002 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 12439864 Disease Relevance 0.23 Pain Relevance 0.63
These effects of AT and cyanamide on ethanol-induced corticosterone values were observed under treatment conditions that decreased significantly brain catalase activity.
Negative_regulation (decreased) of catalase in brain
3) Confidence 0.59 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15608607 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: This study shows that the inhibition of brain catalase increases ethanol-induced plasma corticosterone levels.
Negative_regulation (inhibition) of catalase in plasma
4) Confidence 0.59 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15608607 Disease Relevance 0 Pain Relevance 0
Brain catalase activity inhibition as well as opioid receptor antagonism increases ethanol-induced HPA axis activation.
Negative_regulation (inhibition) of catalase in Brain associated with opioid receptor
5) Confidence 0.59 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Title Doc Link 15608607 Disease Relevance 0 Pain Relevance 0.22
The data suggest that catalase is downregulated at transcriptional levels, resulting in impaired catalase activity in bleomycin-induced lung fibrosis in mice, as was seen in human IP lungs.
Negative_regulation (downregulated) of catalase in lungs associated with fibrosis and pulmonary fibrosis
6) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.37 Pain Relevance 0.15
To assess whether the reduction in catalase activity in fibrotic lungs is due to the decreased synthesis of catalase, we quantified catalase expression in lung tissues using Western blotting and quantitative RT-PCR.
Spec (whether) Negative_regulation (reduction) of catalase in lung associated with fibrosis
7) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.52 Pain Relevance 0.09
To investigate the consequence of decreased catalase activity in the lung during the development of fibrosis, we used acatalasemic mice (C3H/AnLCsbCsb).
Negative_regulation (decreased) of catalase in lung associated with fibrosis
8) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.23 Pain Relevance 0.08
These results show that the diminished catalase activity in the fibrotic lungs is associated with catalase downregulation at the protein and mRNA levels, although it should be noted that this outcome is also related to a difference in the cellularity of homogenized lung tissues between control and fibrotic lungs.
Negative_regulation (diminished) of catalase in lungs associated with fibrosis
9) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.71 Pain Relevance 0.06
Similar to fibrosis, the decrease in catalase at the levels of activity and mRNA expression was also temporal; catalase levels appeared to increase again at 21 days (Figure 3) and tended to become restored at 35 days before the resolution phase (data not shown).
Negative_regulation (decrease) of catalase associated with fibrosis
10) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 1.20 Pain Relevance 0.46
These results show that the diminished catalase activity in the fibrotic lungs is associated with catalase downregulation at the protein and mRNA levels, although it should be noted that this outcome is also related to a difference in the cellularity of homogenized lung tissues between control and fibrotic lungs.
Negative_regulation (downregulation) of catalase in lungs associated with fibrosis
11) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.76 Pain Relevance 0.06
In order to investigate whether catalase activity and mRNA are also decreased during the development of lung fibrosis, C57BL/6J mice were subjected to intratracheal administration of bleomycin.
Spec (whether) Negative_regulation (decreased) of catalase in lung associated with fibrosis and pulmonary fibrosis
12) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.41 Pain Relevance 0.14
Catalase is decreased in bleomycin-induced lung fibrosis in C57BL/6J mice
Negative_regulation (decreased) of Catalase in lung associated with fibrosis and pulmonary fibrosis
13) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.50 Pain Relevance 0.13
NIM administration (8 mg/kg body wt) for 7 days caused significant depletion of the levels of SOD, CAT and reduced GSH, along with the increased levels of lipid peroxidation.
Negative_regulation (depletion) of CAT in body
14) Confidence 0.57 Published 2006 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 17133737 Disease Relevance 0.13 Pain Relevance 0
The decrease in catalase and glutathione peroxidase would result in an increased steady state level of H2O2 and hydroperoxides, contributing to cell injury.
Negative_regulation (decrease) of catalase associated with injury
15) Confidence 0.55 Published 1995 Journal Free Radic. Biol. Med. Section Abstract Doc Link 7557544 Disease Relevance 0.25 Pain Relevance 0.70
Catalase was slightly inhibited (30%) 15 min after acetaminophen administration.
Negative_regulation (inhibited) of Catalase associated with paracetamol
16) Confidence 0.55 Published 1995 Journal Free Radic. Biol. Med. Section Abstract Doc Link 7557544 Disease Relevance 0.21 Pain Relevance 0.69
This suggests that i) 1% DSS model leads to a significant decrease of catalase activity in digestive contents; ii) Lb. casei BL23 exerts natural anti-inflammatory effects by still unknown mechanisms and that iii) the delivery of MnKat catalase has no effect on the development of inflammation in the tested conditions.


Negative_regulation (decrease) of catalase associated with inflammation
17) Confidence 0.53 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.41 Pain Relevance 0.18
Nevertheless, a significant decrease of total catalase activity was observed in digestive contents of 1% DSS-treated mice (Figure 3) and this led us to adopt the 1% DSS model for further experiments to test the antioxidative potential of our strains.


Negative_regulation (decrease) of catalase associated with sprains and strains
18) Confidence 0.53 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.82 Pain Relevance 0.18
Using a colorimetric method, we observed for the first time a significant decrease of the total catalase activity in the intestinal lumen of all DSS-treated mice.
Negative_regulation (decrease) of catalase in intestinal lumen
19) Confidence 0.53 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.73 Pain Relevance 0.13
Acetaminophen challenge (300 mg/kg, i.p) for 7 days caused significant (P < .01) increases in the levels of bilirubin, liver enzymes, TBARS, and iron, while catalase activity and total protein level were reduced significantly (P < .01).
Negative_regulation (reduced) of catalase in liver associated with paracetamol
20) Confidence 0.52 Published 2006 Journal J Med Food Section Abstract Doc Link 17201640 Disease Relevance 0.51 Pain Relevance 0.57

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