INT16722

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 18.55
Pain Relevance 6.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) extracellular space (MPO) oxidoreductase activity (MPO)
aging (MPO) nucleus (MPO) lysosome (MPO)
Anatomy Link Frequency
neutrophils 6
blood 1
MPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 113 100.00 Very High Very High Very High
Bioavailability 5 100.00 Very High Very High Very High
cINOD 45 99.84 Very High Very High Very High
Paracetamol 13 99.58 Very High Very High Very High
lidocaine 12 99.08 Very High Very High Very High
ischemia 88 98.84 Very High Very High Very High
metalloproteinase 17 98.32 Very High Very High Very High
diclofenac 14 98.04 Very High Very High Very High
local anesthetic 1 94.72 High High
Angina 63 92.24 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 193 100.00 Very High Very High Very High
INFLAMMATION 153 100.00 Very High Very High Very High
Death 34 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 2 100.00 Very High Very High Very High
Atherosclerotic Plaque 23 99.50 Very High Very High Very High
Acute Coronary Syndrome 163 99.36 Very High Very High Very High
Rupture 21 98.96 Very High Very High Very High
Reperfusion Injury 16 98.88 Very High Very High Very High
Cv Unclassified Under Development 73 98.84 Very High Very High Very High
Eosinophilia 2 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in models that assess the LDL oxidation, flufenamic acid and its derivatives were unable to properly inhibit MPO activity as the enzyme is adsorbed on macrostructures such as LDL molecules.
Negative_regulation (inhibit) of MPO associated with urological neuroanatomy
1) Confidence 0.59 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610876 Disease Relevance 0.50 Pain Relevance 0.36
An optimum reduction potential enables inhibitors to reduce MPO to compound II, but prevents them from reducing compound II back to the active enzyme.
Negative_regulation (reduce) of MPO associated with urological neuroanatomy
2) Confidence 0.59 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1850278 Disease Relevance 0.50 Pain Relevance 0.16
The characteristic properties that allowed the drugs to inhibit MPO reversibly were ascertained by determining the inhibitory capacity of related phenols and anilines.
Negative_regulation (inhibit) of MPO associated with urological neuroanatomy
3) Confidence 0.59 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1850278 Disease Relevance 0.55 Pain Relevance 0.18
Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs.
Negative_regulation (inhibition) of myeloperoxidase associated with inflammation and cinod
4) Confidence 0.59 Published 1991 Journal Biochem. Pharmacol. Section Title Doc Link 1850278 Disease Relevance 0.49 Pain Relevance 0.23
Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs investigated with a human recombinant enzyme.
Spec (investigated) Negative_regulation (Inhibition) of myeloperoxidase associated with inflammation and cinod
5) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11301057 Disease Relevance 0.19 Pain Relevance 0.37
reduced serum MPO and CRP concentrations in patients with ACS.
Negative_regulation (reduced) of MPO associated with acute coronary syndrome and urological neuroanatomy
6) Confidence 0.59 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.47 Pain Relevance 0.10
Our data shows that the pamidronate treatment provoked a significant increase in the [Ca2+](i) parallel to the enhancement in NO release, suggesting a possible activation of constitutive nitric oxide synthase, while the myeloperoxidase activity was significantly reduced.
Negative_regulation (reduced) of myeloperoxidase
7) Confidence 0.57 Published 2009 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 19238333 Disease Relevance 0.39 Pain Relevance 0.22
The MPO-ANCA level decreased to its lowest value, and renal function was ameliorated within 3 months.
Negative_regulation (decreased) of MPO associated with urological neuroanatomy
8) Confidence 0.57 Published 1997 Journal Nephron Section Abstract Doc Link 9380224 Disease Relevance 1.34 Pain Relevance 0.08
Direct inhibition of the chlorinating activity of myeloperoxidase (MPO) was confirmed using highly purified human enzyme in vitro.
Negative_regulation (inhibition) of MPO associated with urological neuroanatomy
9) Confidence 0.55 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1848981 Disease Relevance 0.33 Pain Relevance 0.19
Direct inhibition of the chlorinating activity of myeloperoxidase (MPO) was confirmed using highly purified human enzyme in vitro.
Negative_regulation (inhibition) of myeloperoxidase associated with urological neuroanatomy
10) Confidence 0.55 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1848981 Disease Relevance 0.33 Pain Relevance 0.19
The identification of the oxidation products confirms that flufenamic behaves like an electron donor and is directly oxidized in the 5-hydroxy-derivative but gives also the 5-chloro-derivative which similarly inhibits the MPO/H(2)O(2)/Cl(-) system.
Negative_regulation (inhibits) of MPO associated with urological neuroanatomy
11) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610876 Disease Relevance 0.56 Pain Relevance 0.50
In this paper, we report that meclofenamic acid inhibited myeloperoxidase-dependent hydroxyl radical generation through scavenging of hypochlorous acid and not by direct inhibition of myeloperoxidase.
Negative_regulation (inhibition) of myeloperoxidase
12) Confidence 0.43 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7748188 Disease Relevance 0.48 Pain Relevance 0.31
Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid.
Negative_regulation (Inhibition) of myeloperoxidase associated with inflammation and cinod
13) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17610876 Disease Relevance 0.63 Pain Relevance 0.43
Overall, these data indicate that acetaminophen may be an important modulator of MPO activity in vivo.
Negative_regulation (modulator) of MPO associated with paracetamol and urological neuroanatomy
14) Confidence 0.43 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19968966 Disease Relevance 0.25 Pain Relevance 0.93
We found that lidocaine added to human neutrophils in vitro markedly impaired the release of superoxide anion (O2-) and the granule enzymes lysozyme and myeloperoxidase after stimulation by phorbol myristate acetate or opsonized zymosan.
Negative_regulation (impaired) of myeloperoxidase in neutrophils associated with lidocaine
15) Confidence 0.37 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2997433 Disease Relevance 0.26 Pain Relevance 0.83
It has recently recognized that polymorphonuclear neutrophils (PMNs) are critical mediators in ACS, because of their recruitment and activation before platelet aggregation.46 One of the principal mediators secreted on PMN activation is myeloperoxidase (MPO), a hemoproteine that is a microbicidal enzyme, but it has also potent proatherogenic properties: infact, MPO can oxidize LDL cholesterol, amplificating uptake by macrophages and perpetuating foam cell formation.47 Moreover, MPO promotes activation of metalloproteinases and destabilization and rupture of atherosclerotic plaques surface.48 Furthermore, MPO catalytically consumes endothelium-derived nitric oxide, reducing its bioavailability and impairing its vasodilatory and anti-inflammatory functions.49
Negative_regulation (impairing) of MPO in PMNs associated with atherosclerotic plaque, acute coronary syndrome, inflammation, rupture, metalloproteinase, urological neuroanatomy and bioavailability
16) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 2.04 Pain Relevance 0.32
Some authors found that MPO serum levels were equally distributed among patients with low and high Troponin T (TnT) serum levels, which indicates that elevated MPO levels are not temporary related to myocardial injury.47 Moreover, MPO identifies patients at risk for cardiovascular events who have low baseline TnT levels, even before complete microvascular obstruction.
Negative_regulation (distributed) of MPO associated with injury and urological neuroanatomy
17) Confidence 0.34 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.75 Pain Relevance 0.30
To determine the mode of protective effects of misoprostol against the chronic gastrointestinal ulceration from the NSAID, diclofenac, studies were undertaken in domestic pigs, a model of human gastrointestinal ulceration, to determine (1) the effects of repeated daily dosing for 10 days of diclofenac 5 mg/kg/day twice a day (as Voltaren tablets) on the gastrointestinal morphology, 59fe-red blood loss, mucosal myeloperoxidase (MPO) activity (as an indicator of leukocyte infiltration), and mucosal leukotrienes (LTS); and (2) the mucosal protective effects of 10-40 micrograms/kg/day misoprostol twice a day (as Cytotec tablets) given with diclofenac 5 mg/kg/day twice a day compared with diclofenac 5 mg/kg/day alone and aspirin 150 mg/kg/twice a day (USP tablets) as a standard.
Negative_regulation (loss) of myeloperoxidase in blood associated with aspirin, pressure volume 2 under development, cinod, urological neuroanatomy and diclofenac
18) Confidence 0.24 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7628265 Disease Relevance 0.20 Pain Relevance 0.47
In addition, lysosomal enzyme secretion, such as elastase or myeloperoxidase as well as superoxide generation in human neutrophils were also reduced in a similar range.
Negative_regulation (reduced) of myeloperoxidase in neutrophils
19) Confidence 0.24 Published 2006 Journal Life Sci. Section Abstract Doc Link 16360707 Disease Relevance 0 Pain Relevance 0.16
In this study MPO, sCD40L and MMP-9 levels were not independently associated with death, whereas patients with increased levels of PIGF, NT-proBNP, CRP, cTnI or decreased eGFR had higher mortality rate than patients with normal value of these biomarkers.
Neg (not) Negative_regulation (decreased) of MPO associated with urological neuroanatomy and death
20) Confidence 0.22 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.32 Pain Relevance 0

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