INT16723

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Context Info
Confidence 0.11
First Reported 1989
Last Reported 2009
Negated 5
Speculated 2
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 4.30
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
plasma 1
cleavage 1
stomach mucosa 1
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 1 100.00 Very High Very High Very High
aspirin 21 99.60 Very High Very High Very High
Paracetamol 12 99.54 Very High Very High Very High
Pain 17 98.68 Very High Very High Very High
Morphine 9 98.48 Very High Very High Very High
adenocard 1 97.76 Very High Very High Very High
Analgesic 2 95.76 Very High Very High Very High
cerebral cortex 2 93.08 High High
Inflammation 8 91.40 High High
cINOD 10 83.36 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 99.56 Very High Very High Very High
Pain 20 98.68 Very High Very High Very High
Anxiety Disorder 1 98.32 Very High Very High Very High
Leukemia 1 97.72 Very High Very High Very High
Fabry Disease 146 97.60 Very High Very High Very High
Lysosome Storage Disease 4 96.46 Very High Very High Very High
Breast Cancer 4 92.96 High High
Disease 85 92.52 High High
INFLAMMATION 13 91.40 High High
Cancer 6 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substrate and product concentrations can alter the activity of the allosteric enzyme, phosphofructokinase, which may control the oscillations in ATP concentration.
Regulation (alter) of enzyme
1) Confidence 0.11 Published 1989 Journal J. Invest. Dermatol. Section Abstract Doc Link 2502581 Disease Relevance 0 Pain Relevance 0.11
In the end, we demonstrate the ability of ASA and SA to directly modulate an important regulatory intracellular enzyme, and propose that this is one of their mechanisms promoting anti-tumoral effects.
Regulation (modulate) of enzyme associated with aspirin
2) Confidence 0.04 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 18851958 Disease Relevance 0.35 Pain Relevance 0.35
We show that ASA and SA inhibit purified PFK in a dose-dependent manner, and that this inhibition occurs due to the modulation of the enzyme quaternary structure.
Regulation (modulation) of enzyme associated with aspirin
3) Confidence 0.04 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 18851958 Disease Relevance 0.47 Pain Relevance 0.42
The molecular regulation of UGT enzyme is still not fully understood, but various transcription factors appear to play a regulatory role.
Regulation (regulation) of enzyme
4) Confidence 0.01 Published 2005 Journal Pharmacol. Ther. Section Abstract Doc Link 15781124 Disease Relevance 0 Pain Relevance 0.25
In contrast, acetaminophen did not significantly affect the DNA cleavage activity of the human enzyme in vitro or in cultured CEM cells.
Neg (not) Regulation (affect) of enzyme in cleavage associated with paracetamol
5) Confidence 0.01 Published 2004 Journal Biochemistry Section Abstract Doc Link 15035644 Disease Relevance 0.30 Pain Relevance 0.46
Evidence is accumulating that COX-2 might not only be considered as a putatively detrimental enzyme but rather a highly regulated enzyme that also contributes to tissue protection and is even constitutively expressed in healthy human stomach mucosa.
Regulation (regulated) of enzyme in stomach mucosa
6) Confidence 0.01 Published 2000 Journal Curr. Med. Chem. Section Abstract Doc Link 11032962 Disease Relevance 0.37 Pain Relevance 0.40
It is possible that there are factors in plasma that may adversely affect the circulating enzyme whose optimal activity is within the acidified environment of the lysosome.
Spec (may) Regulation (affect) of enzyme in plasma
7) Confidence 0.01 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721310 Disease Relevance 0.57 Pain Relevance 0
Fatty acid amide hydrolase (FAAH), a membrane-anchored enzyme responsible for the termination of endocannabinoid signalling, is an attractive target for treating conditions such as pain and anxiety.
Regulation (target) of enzyme associated with pain, endocannabinoid and anxiety disorder
8) Confidence 0.01 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.20 Pain Relevance 0.15
The enzyme activity responsible for the formation of morphinone from morphine was mainly localized in the microsomes.
Regulation (responsible) of enzyme associated with morphine
9) Confidence 0.01 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15997113 Disease Relevance 0 Pain Relevance 0.64
The activated species irreversibly alters the enzyme to remove it permanently from the pool of active enzyme.
Regulation (alters) of enzyme
10) Confidence 0.00 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661603 Disease Relevance 0.08 Pain Relevance 0
The activated species irreversibly alters the enzyme to remove it permanently from the pool of active enzyme.
Regulation (alters) of enzyme
11) Confidence 0.00 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661603 Disease Relevance 0 Pain Relevance 0.13
Polymorphisms in the 5’-untranslated region could affect the affinity for transcription enhancers and thereby affect AGAL transcription, which could explain altered enzyme activity and even tissue-specific phenotypic expression of Fabry disease in rare patients for whom coding region or splice-site mutations cannot be readily identified (Oliveira et al 2008).


Regulation (altered) of enzyme associated with fabry disease
12) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.89 Pain Relevance 0
In addition, there is accumulating evidence in a number of lysosomal storage disorders that antibodies generated against infused recombinant enzyme can also interfere with mannose-6-phosphate-mediated receptor uptake, even though the antibodies may not affect the specific activity of the enzyme.
Neg (not) Spec (may) Regulation (affect) of enzyme associated with lysosome storage disease
13) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.22 Pain Relevance 0.03
Evidence shows that homo- and heterozygotic expression of UGT1A6 alleles markedly affects enzyme activity.
Regulation (affects) of enzyme
14) Confidence 0.00 Published 2005 Journal Meth. Enzymol. Section Abstract Doc Link 16399343 Disease Relevance 0.08 Pain Relevance 0.21
In contrast to its inhibition of the oxidation of Cl- by MPO, indomethacin had no effect on the peroxidative activity of the enzyme (oxidation of 4-aminoantipyrene), nor did it inhibit the activity of several other enzymes involved in H2O2 metabolism, including horseradish peroxidase, catalase, xanthine oxidase, and superoxide dismutase.
Neg (no) Regulation (effect) of enzyme associated with urological neuroanatomy
15) Confidence 0.00 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1848981 Disease Relevance 0.33 Pain Relevance 0.28
In contrast, TRAP and the antioxidant enzyme activities were not altered by the metabolite.
Neg (not) Regulation (altered) of enzyme
16) Confidence 0.00 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12786967 Disease Relevance 0.46 Pain Relevance 0.16
Expression of the cDNAs in COS-1 cells revealed that the CYP2D6 17 enzyme displayed only 20% of the wild-type (CYP2D6 1) activity, whereas the T107I substitution on its own had no significant effect on enzyme function.
Neg (no) Regulation (effect) of enzyme
17) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415713 Disease Relevance 0 Pain Relevance 0.07
A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function.
Regulation (alterations) of enzyme
18) Confidence 0.00 Published 1997 Journal Mol. Pharmacol. Section Title Doc Link 9415713 Disease Relevance 0 Pain Relevance 0.05

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