INT167270

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.48
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
neurons 8
plasma 6
heart 2
respiratory 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 68 98.32 Very High Very High Very High
imagery 11 94.48 High High
methadone 78 94.40 High High
cocaine 32 93.36 High High
tolerance 2 86.20 High High
anesthesia 17 83.24 Quite High
cytokine 55 82.56 Quite High
opiate 4 78.04 Quite High
Abstinence syndrome 6 77.24 Quite High
Inflammation 61 76.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 479 100.00 Very High Very High Very High
Lipodystrophy 1 99.82 Very High Very High Very High
Opiate Addiction 4 99.64 Very High Very High Very High
Infection 5 98.76 Very High Very High Very High
Hypercapnia 20 98.24 Very High Very High Very High
Osteoporosis 10 96.60 Very High Very High Very High
Diabetes Mellitus 104 94.16 High High
Obesity-hypoventilation Syndrome 56 92.84 High High
Autoimmune Disease 7 91.76 High High
Starvation 4 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in neurons with reduced leptin receptor expression, the ability of leptin (50 nM; 30 min) to alter the density of dendritic filopodia was significantly reduced such that the mean density of filopodia was 1.37 ± 0.15 (n = 36) and 1.48 ± 0.13 (n = 36; P > 0.05) in the absence and presence of leptin, respectively.
Negative_regulation (reduced) of Gene_expression (expression) of leptin in neurons
1) Confidence 0.55 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
M), had no effect on the density of filopodia per se (mean density of 2.47 ± 0.56; n = 10; P > 0.05), but it prevented the leptin-induced morphogenesis, such that the mean density of filopodia following exposure to leptin was 2.51 ± 0.62 (n = 11; P > 0.05; Fig. 6C) in neurons incubated with U0126 (1 ?
Negative_regulation (prevented) of Gene_expression (morphogenesis) of leptin-induced in neurons
2) Confidence 0.40 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
In order to demonstrate that the changes in dendritic morphology induced by leptin were attributable to activation of leptin receptors, the effects of leptin were also assessed in neurons transfected with leptin receptor siRNA to reduce leptin receptor expression.
Negative_regulation (reduce) of Gene_expression (expression) of leptin in neurons
3) Confidence 0.40 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
These data suggest that the alterations in dendritic morphology induced by leptin are mediated by activation of leptin receptors as genetic knockdown of leptin receptor expression in hippocampal neurons markedly attenuated the effects of this hormone.
Negative_regulation (knockdown) of Gene_expression (expression) of leptin in neurons
4) Confidence 0.40 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
As with fasting, the reduction in plasma leptin could largely be a reflection of the reduction in adipose weight, as well as plasma insulin.
Negative_regulation (reduction) of Gene_expression (reflection) of leptin in plasma
5) Confidence 0.39 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.21 Pain Relevance 0
As with fasting, the reduction in plasma leptin could largely be a reflection of the reduction in adipose weight, as well as plasma insulin.
Negative_regulation (reduction) of Gene_expression (reflection) of leptin in plasma
6) Confidence 0.39 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.21 Pain Relevance 0
It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility.
Negative_regulation (reduced) of Gene_expression (production) of leptin associated with infection
7) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2846344 Disease Relevance 0.63 Pain Relevance 0.11
Thus, during fasting period and after reduction of body fat mass, there is a decrease in leptin levels that leads to a reduction in total energy expenditure to provide enough energy for the function of vital organs, that is, the brain, the heart, and the liver [4].
Negative_regulation (decrease) of Gene_expression (levels) of leptin in heart
8) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.49 Pain Relevance 0.07
In addition, studies have shown that commencing CPAP therapy at least a week before surgery helps improve UA collapsibility, reduce leptin levels, and augment respiratory drive and chemoresponsiveness. 27

Conclusion

Negative_regulation (reduce) of Gene_expression (levels) of leptin in respiratory
9) Confidence 0.33 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.57 Pain Relevance 0.08
Furthermore, in OSA with chronic hypercapnia, the leptin levels were even higher.44 Finally, Chin et al45 demonstrated a noticeable reduction in leptin levels following CPAP treatment.45 All these studies propose an important role of leptin and highlight the potential significance of the development of leptin resistance in obesity and OHS.
Negative_regulation (reduction) of Gene_expression (levels) of leptin associated with obesity, hypercapnia and obesity-hypoventilation syndrome
10) Confidence 0.33 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.37 Pain Relevance 0.04
triglyceride levels in obese monkeys, raises high-density lipoprotein levels,
Negative_regulation (levels) of Gene_expression (monkeys) of obese associated with obesity
11) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.56 Pain Relevance 0.18
Plasma insulin and glucose levels were reduced, and leptin levels were very low; however, plasma triglycerides, cholesterol, phospholipids, and fatty acids were normal.
Negative_regulation (low) of Gene_expression (levels) of leptin in Plasma
12) Confidence 0.27 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20357015 Disease Relevance 0.17 Pain Relevance 0.13
It can therefore be assumed that heroin abuse in pregnancy may reduce placental leptin synthesis and contributes to IUGR by reducing fetal growth.
Negative_regulation (reduce) of Gene_expression (synthesis) of leptin associated with opiate addiction
13) Confidence 0.18 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2703629 Disease Relevance 0.61 Pain Relevance 0.53
In association to lipodystrophy, strong reduction of leptin levels was observed, known to enhance bone formation in mice and humans [46].
Negative_regulation (reduction) of Gene_expression (levels) of leptin associated with lipodystrophy
14) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.65 Pain Relevance 0.04

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