INT167283

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 7.94
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
nucleus 2
blood cells 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 13 100.00 Very High Very High Very High
Hippocampus 26 98.56 Very High Very High Very High
Kinase C 67 97.84 Very High Very High Very High
Dopamine 4 97.20 Very High Very High Very High
antidepressant 12 97.12 Very High Very High Very High
adenocard 1 85.36 High High
Eae 90 73.72 Quite High
addiction 2 62.08 Quite High
depression 26 53.32 Quite High
Inflammation 10 51.36 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 379 99.80 Very High Very High Very High
Depression 42 98.52 Very High Very High Very High
Manic Depressive Disorder 85 98.20 Very High Very High Very High
Stress 18 97.76 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 45 97.20 Very High Very High Very High
Cancer 108 96.72 Very High Very High Very High
Disease 247 94.24 High High
Cognitive Disorder 30 90.08 High High
Neurodegenerative Disease 38 89.04 High High
Bullous Skin Disease 304 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, serine-phosphorylation of GSK3 was reduced during both mood-related behavioral responses in wild-type mouse brain and in blood cells from patients with bipolar disorder.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of GSK3 in blood cells associated with manic depressive disorder
1) Confidence 0.59 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.68 Pain Relevance 0.04
Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.
Negative_regulation (Deficiency) of Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with pain
2) Confidence 0.43 Published 2010 Journal Neuropsychopharmacology Section Title Doc Link 20357757 Disease Relevance 0.61 Pain Relevance 0.35
This was tested by measuring behavioral characteristics of GSK3 alpha/beta(21A/21A/9A/9A) knockin mice with serine-to-alanine mutations to block inhibitory serine-phosphorylation of GSK3.
Negative_regulation (block) of Phosphorylation (phosphorylation) of GSK3
3) Confidence 0.43 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.66 Pain Relevance 0.04
Because mood stabilizers, antipsychotics, antidepressants, and mood-regulating neuromodulators increase the inhibitory serine-phosphorylation of glycogen synthase kinase-3 (GSK3), we hypothesized that deficient GSK3 serine-phosphorylation may increase vulnerability to mood-related behavioral disturbances.
Negative_regulation (deficient) of Phosphorylation (phosphorylation) of GSK3 associated with antidepressant
4) Confidence 0.43 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.54 Pain Relevance 0.05
These decreases in levels of phosphorylated Akt and GSK3?
Negative_regulation (decreases) of Phosphorylation (phosphorylated) of GSK3
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.93 Pain Relevance 0.08
KO mice, we assessed the phosophorylation levels of Akt and GSK3?
Negative_regulation (assessed) of Phosphorylation (phosophorylation) of GSK3 associated with targeted disruption
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.28 Pain Relevance 0.20
The total and phosohorylation levels of Akt and GSK3?
Negative_regulation (levels) of Phosphorylation (phosohorylation) of GSK3
7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.78 Pain Relevance 0.10
KO mice are partly caused by the reduced phosphorylation levels of Akt and GSK3?.
Negative_regulation (levels) of Phosphorylation (phosphorylation) of GSK3 associated with targeted disruption
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.03
There are two major pathways by which lithium is known to affect the activities of multiple transcription factors that control gene expression, and both of these pathways involve inhibitory effects on GSK3: lithium can act as a competitive inhibitor of Mg2+, thereby reducing GSK3 activity [14]; lithium also inhibits GSK3 by increasing the inhibitory phosphorylation of a Ser-9 residue in GSK3?
Negative_regulation (inhibitory) of Phosphorylation (phosphorylation) of GSK3
9) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.11 Pain Relevance 0
There are two major pathways by which lithium is known to affect the activities of multiple transcription factors that control gene expression, and both of these pathways involve inhibitory effects on GSK3: lithium can act as a competitive inhibitor of Mg2+, thereby reducing GSK3 activity [14]; lithium also inhibits GSK3 by increasing the inhibitory phosphorylation of a Ser-9 residue in GSK3?
Negative_regulation (residue) of Phosphorylation (phosphorylation) of GSK3
10) Confidence 0.27 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.11 Pain Relevance 0
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Negative_regulation (abolished) of Phosphorylation (phosphorylation) of GSK3 in nucleus
11) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.44 Pain Relevance 0.03
by competing for Mg2+, followed by the inactivation of Protein Phosphatase 1 and subsequent increased inhibitory phosphorylation of GSK3?
Negative_regulation (inactivation) of Phosphorylation (phosphorylation) of GSK3
12) Confidence 0.11 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.44 Pain Relevance 0.03
The antisense induced knockdown of Dkk-1 attenuates the reduction in the phosphorylated (inhibited) form of GSK-3?
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of GSK-3
13) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.49 Pain Relevance 0.09
This possibility is given by the fact that Wnt stimulates the mTOR signalling pathway via inhibiting GSK3 phosphorylation of TSC2.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of GSK3
14) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0.04
The antisense induced knockdown of Dkk-1 attenuates the reduction in the phosphorylated (inhibited) form of GSK-3?
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of GSK-3
15) Confidence 0.06 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.49 Pain Relevance 0.09

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