INT167284

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Context Info
Confidence 0.82
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 88
Total Number 89
Disease Relevance 36.03
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neurons 3
liver 1
dentate gyrus 1
brain 1
striatum 1
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 532 100.00 Very High Very High Very High
Serotonin 18 99.66 Very High Very High Very High
Pain 39 99.28 Very High Very High Very High
antidepressant 53 98.62 Very High Very High Very High
Hippocampus 181 98.56 Very High Very High Very High
Kinase C 266 97.84 Very High Very High Very High
Dopamine 84 97.64 Very High Very High Very High
Neurotransmitter 10 97.32 Very High Very High Very High
Immobilon 18 95.80 Very High Very High Very High
depression 115 90.56 High High
Disease Link Frequency Relevance Heat
Disease 1147 99.76 Very High Very High Very High
Apoptosis 241 99.64 Very High Very High Very High
Targeted Disruption 2191 99.54 Very High Very High Very High
Sprains And Strains 127 99.54 Very High Very High Very High
Alagille Syndrome 176 99.06 Very High Very High Very High
Manic Depressive Disorder 337 98.76 Very High Very High Very High
Familial Adenomatous Polyposis 29 98.56 Very High Very High Very High
Depression 167 98.52 Very High Very High Very High
Stomach Cancer 180 98.44 Very High Very High Very High
Parkinson's Disease 638 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because mood stabilizers, antipsychotics, antidepressants, and mood-regulating neuromodulators increase the inhibitory serine-phosphorylation of glycogen synthase kinase-3 (GSK3), we hypothesized that deficient GSK3 serine-phosphorylation may increase vulnerability to mood-related behavioral disturbances.
Phosphorylation (phosphorylation) of GSK3 associated with antidepressant
1) Confidence 0.82 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.53 Pain Relevance 0.05
Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.
Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with pain
2) Confidence 0.82 Published 2010 Journal Neuropsychopharmacology Section Title Doc Link 20357757 Disease Relevance 0.61 Pain Relevance 0.34
This was tested by measuring behavioral characteristics of GSK3 alpha/beta(21A/21A/9A/9A) knockin mice with serine-to-alanine mutations to block inhibitory serine-phosphorylation of GSK3.
Phosphorylation (phosphorylation) of GSK3
3) Confidence 0.82 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.65 Pain Relevance 0.04
Because mood stabilizers, antipsychotics, antidepressants, and mood-regulating neuromodulators increase the inhibitory serine-phosphorylation of glycogen synthase kinase-3 (GSK3), we hypothesized that deficient GSK3 serine-phosphorylation may increase vulnerability to mood-related behavioral disturbances.
Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with antidepressant
4) Confidence 0.82 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.48 Pain Relevance 0.05
Therefore, proper control of GSK3 by serine-phosphorylation, which is targeted by agents therapeutic for bipolar disorder, is an important mechanism that regulates mood stabilization, and mice with disabled GSK3 serine-phosphorylation may provide a valuable model to study bipolar disorder.
Phosphorylation (phosphorylation) of GSK3 associated with manic depressive disorder
5) Confidence 0.82 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.75 Pain Relevance 0.03
Furthermore, serine-phosphorylation of GSK3 was reduced during both mood-related behavioral responses in wild-type mouse brain and in blood cells from patients with bipolar disorder.
Phosphorylation (phosphorylation) of GSK3 in blood cells associated with manic depressive disorder
6) Confidence 0.82 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.68 Pain Relevance 0.04
GSK-3 has been shown to phosphorylate and inhibit GR [99].
Phosphorylation (phosphorylate) of GSK-3
7) Confidence 0.74 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.37 Pain Relevance 0.37
Additionally, our results showing that LiCl (200 mg/kg i.p.) did not affect locomotor activity in WT mice (Figure 2c) may support the results of Akt and GSK3 phosphorylation in WT cortex.
Phosphorylation (phosphorylation) of GSK3 in cortex associated with eae
8) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.25 Pain Relevance 0.08
Effects of lithium on Akt and GSK3 phosphorylation may vary depending upon the brain region or the mouse strain.
Phosphorylation (phosphorylation) of GSK3 in brain associated with sprains and strains
9) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.41 Pain Relevance 0.04
Some reports have shown that lithium affects both Akt and GSK3 phosphorylation in the striatum of WT animals [36].
Phosphorylation (phosphorylation) of GSK3 in striatum
10) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.36 Pain Relevance 0.04
On the other hand, in the present study we focused solely on the cortical changes of Akt and GSK3 phosphorylation.
Phosphorylation (phosphorylation) of GSK3
11) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.41 Pain Relevance 0.04
The effects of lithium on phosphorylated Akt and GSK3?
Phosphorylation (phosphorylated) of GSK3
12) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.90 Pain Relevance 0.08
These decreases in levels of phosphorylated Akt and GSK3?
Phosphorylation (phosphorylated) of GSK3
13) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.92 Pain Relevance 0.08
KO mice are partly caused by the reduced phosphorylation levels of Akt and GSK3?.
Phosphorylation (phosphorylation) of GSK3 associated with targeted disruption
14) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.03
Phosphorylation levels of Akt and GSK3?
Phosphorylation (Phosphorylation) of GSK3
15) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.98 Pain Relevance 0.11
KO mice, we assessed the phosophorylation levels of Akt and GSK3?
Phosphorylation (phosophorylation) of GSK3 associated with targeted disruption
16) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.27 Pain Relevance 0.20
are one of target proteins of lithium; lithium increases the phosphorylation levels of Akt and GSK3?
Phosphorylation (phosphorylation) of GSK3
17) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.02 Pain Relevance 0.07
For immunoblotting, the following primary antibodies were used: Anti-phospho-Akt (Ser473) (193H12) rabbit mAb, phospho-Akt (Thr308) (C31E5E) rabbit mAb, Akt rabbit Ab, phospho-GSK3?
Phosphorylation (phospho) of GSK3
18) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0 Pain Relevance 0.05
(27C10) rabbit mAb, phospho-GSK3?
Phosphorylation (phospho) of GSK3
19) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0 Pain Relevance 0.04
On the other hand, GSK activity reflected the ratio of phosphor-Ser9 GSK3?
Phosphorylation (phosphor) of GSK3
20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.59 Pain Relevance 0

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