INT167285

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 5.92
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
muscle tissues 3
dentate gyrus 2
liver 1
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 11 99.28 Very High Very High Very High
antidepressant 4 99.24 Very High Very High Very High
Eae 50 93.12 High High
ischemia 6 88.84 High High
Kinase C 32 78.08 Quite High
Dopamine 28 62.32 Quite High
Inflammation 8 51.36 Quite High
tolerance 38 39.40 Quite Low
depression 13 28.12 Quite Low
dexamethasone 10 15.44 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 77 99.54 Very High Very High Very High
Targeted Disruption 250 99.40 Very High Very High Very High
Manic Depressive Disorder 38 98.60 Very High Very High Very High
Depression 19 96.48 Very High Very High Very High
Disease 299 95.32 Very High Very High Very High
Cancer 174 92.00 High High
Cv Unclassified Under Development 6 88.84 High High
Neurodegenerative Disease 47 87.84 High High
Death 94 84.68 Quite High
Stress 24 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with pain
1) Confidence 0.50 Published 2010 Journal Neuropsychopharmacology Section Title Doc Link 20357757 Disease Relevance 0.62 Pain Relevance 0.34
Because mood stabilizers, antipsychotics, antidepressants, and mood-regulating neuromodulators increase the inhibitory serine-phosphorylation of glycogen synthase kinase-3 (GSK3), we hypothesized that deficient GSK3 serine-phosphorylation may increase vulnerability to mood-related behavioral disturbances.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with antidepressant
2) Confidence 0.47 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20357757 Disease Relevance 0.48 Pain Relevance 0.05
are one of target proteins of lithium; lithium increases the phosphorylation levels of Akt and GSK3?
Positive_regulation (increases) of Phosphorylation (phosphorylation) of GSK3
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.03 Pain Relevance 0.07
Indeed, the level of insulin-induced phosphorylation of PKB and GSK-3 was similar in liver and muscle tissues of both Alb Cre + and Alb Cre – mice (figure 5A and 5B respectively).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GSK-3 in muscle tissues
4) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.38 Pain Relevance 0
Chronic administration of lithium to mice has been shown to cause an increase in the phosphorylation of Ser-9 of GSK3?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GSK3
5) Confidence 0.32 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0 Pain Relevance 0
There are two major pathways by which lithium is known to affect the activities of multiple transcription factors that control gene expression, and both of these pathways involve inhibitory effects on GSK3: lithium can act as a competitive inhibitor of Mg2+, thereby reducing GSK3 activity [14]; lithium also inhibits GSK3 by increasing the inhibitory phosphorylation of a Ser-9 residue in GSK3?
Positive_regulation (increasing) of Phosphorylation (phosphorylation) of GSK3
6) Confidence 0.32 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.11 Pain Relevance 0
greatly enhanced BMAL1 ubiquitylation, whereas co-expression of KD-GSK3?
Positive_regulation (enhanced) of Phosphorylation (ubiquitylation) of GSK3
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
To prove that S17 and T21 are directly phosphorylated by GSK3?
Positive_regulation (directly) of Phosphorylation (phosphorylated) of GSK3
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
To prove that S17 and T21 are directly phosphorylated by GSK3?
Positive_regulation (by) of Phosphorylation (phosphorylated) of GSK3
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
Previously generated transgenic mice which overexpress GSK-3 in the dentate gyrus were crossed with a tau knockout strain in order to verify if GSK-3 mediated phosphorylation of tau is the cause of neurodegeneration in the dentate gyrus.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of GSK-3 in dentate gyrus associated with targeted disruption and sprains and strains
10) Confidence 0.29 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 1.07 Pain Relevance 0.05
Western analyses confirmed that co-expression of CA-Akt indeed caused an increase in phosphorylation of GSK3?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GSK3
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
antibodies we reveal that there is more phosphorylation of GSK3?
Positive_regulation (more) of Phosphorylation (phosphorylation) of GSK3
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.08 Pain Relevance 0
Thus, MPP+ does not appear to regulate the Akt-mediated phosphorylation of GSK-3?
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of GSK-3
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.52 Pain Relevance 0.03
Therefore, the active form of GSK-3?
Positive_regulation (active) of Phosphorylation (form) of GSK-3
14) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.28 Pain Relevance 0.04
by competing for Mg2+, followed by the inactivation of Protein Phosphatase 1 and subsequent increased inhibitory phosphorylation of GSK3?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GSK3
15) Confidence 0.17 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.44 Pain Relevance 0.03
Indeed, the level of insulin-induced phosphorylation of PKB and GSK-3 was similar in liver and muscle tissues of both Alb Cre + and Alb Cre – mice (figure 5A and 5B respectively).
Positive_regulation (induced) of in liver Phosphorylation (phosphorylation) of GSK-3 in muscle tissues
16) Confidence 0.13 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.38 Pain Relevance 0
-catenin is phosphorylated by GSK3?
Positive_regulation (by) of Phosphorylation (phosphorylated) of GSK3
17) Confidence 0.12 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.06 Pain Relevance 0.05
Dkk-1 negatively modulates the canonical Wnt signaling pathway, thus activating the tau-phosphorylating enzyme GSK-3?
Positive_regulation (activating) of Phosphorylation (phosphorylating) of GSK-3
18) Confidence 0.08 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.48 Pain Relevance 0.16

General Comments

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