INT16729

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Context Info
Confidence 0.65
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.63
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LOC308670) transmembrane transport (LOC308670)
Anatomy Link Frequency
inner surface 1
neuronal 1
middle cerebral artery 1
cortex 1
LOC308670 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 6 100.00 Very High Very High Very High
analgesia 8 98.60 Very High Very High Very High
Morphine 2 98.08 Very High Very High Very High
antagonist 57 96.96 Very High Very High Very High
imagery 70 96.04 Very High Very High Very High
agonist 8 95.80 Very High Very High Very High
Pain 1 94.16 High High
Enkephalin 2 94.00 High High
Central nervous system 6 92.16 High High
acular 11 91.28 High High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 11 100.00 Very High Very High Very High
Stress 7 97.58 Very High Very High Very High
Body Weight 3 94.56 High High
Pain 1 94.16 High High
Pressure And Volume Under Development 19 89.88 High High
Cerebral Infarction 78 85.08 High High
Cv Unclassified Under Development 23 84.64 Quite High
Anxiety Disorder 3 75.00 Quite High
Stroke 37 50.00 Quite Low
Emergencies 1 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in logP and capacity factor values of the prodrugs were observed in proportion to their alkyl chain length.
Positive_regulation (increase) of logP
1) Confidence 0.65 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12712420 Disease Relevance 0 Pain Relevance 0.50
AA in the hypophysectomized rats, and enhanced neuronal activity in the P-HARN that were abolished during acupuncture stimulation, were both restored by intraperitoneal microinjection of 0.5 mg/kg morphine or 0.1 micrograms beta-endorphin into the P-HARN during acupuncture stimulation.
Positive_regulation (restored) of P-HARN in neuronal associated with acupuncture, morphine and analgesia
2) Confidence 0.09 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1849781 Disease Relevance 0.09 Pain Relevance 1.20
In the choroid plexus, the ouabain-sensitive electron-dense reaction products of NA+, K+-ATPase (p-NPPase) were strongly positive in the microvilli and along the inner surface of microvilli, without showing any Mg2+-ATPase and AC activities, and all three enzymatic activities were positive along the basal plasmalemmas and negative along the lateral and apical (not including microvilli) plasmalemmas.
Positive_regulation (positive) of p-NPPase in inner surface
3) Confidence 0.03 Published 1981 Journal Brain Res. Section Abstract Doc Link 6116520 Disease Relevance 0 Pain Relevance 0.06
All experimental subjects underwent pMCAO.
Positive_regulation (underwent) of pMCAO
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890583 Disease Relevance 0 Pain Relevance 0.16
No induction in the pPVN was observed 1 and 3 days after thyroidectomy, and no effects attributable specifically to thyroidectomy (as opposed to stress) on Fos expression in the mPVN, AH, LH, or pyriform cortex were observed.
Neg (No) Positive_regulation (induction) of pPVN in cortex associated with stress
5) Confidence 0.01 Published 1991 Journal Endocrinology Section Abstract Doc Link 1954900 Disease Relevance 0.18 Pain Relevance 0.14
In addition, a rapid, stress-related, induction of Fos-like IR was detected in the mPVN, AH, and LH and was easily distinguished from Fos expression induced in the pPVN as a function of thyroidectomy.
Positive_regulation (induced) of pPVN associated with stress
6) Confidence 0.01 Published 1991 Journal Endocrinology Section Abstract Doc Link 1954900 Disease Relevance 0.19 Pain Relevance 0.11
The 5-HT2C/1B receptor agonist m-CPP, the inverse BZD receptor agonists FG 7142 and DMCM, and the alpha 2-adrenoceptor antagonist yohimbine, to all of which putative anxiogenic effects have been ascribed, had no effect on SAP directed towards the prod. m-CPP, however, produced an increase in the stretched posture directed away from the prod (SAwayP).
Positive_regulation (increase) of SAwayP associated with antagonist and agonist
7) Confidence 0.01 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.55
Drugs were given intraperitoneally 30 min before inducing pMCAO.
Positive_regulation (inducing) of pMCAO
8) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2259310 Disease Relevance 0.31 Pain Relevance 0.05
Induction of permanent middle cerebral artery occlusion (pMCAO) in the rat
Positive_regulation (Induction) of pMCAO in middle cerebral artery associated with middle cerebral artery infarction
9) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2259310 Disease Relevance 0.40 Pain Relevance 0.30
Animals given tropisetron displayed a significant increase in the neurological deficits at 24 h after pMCAO.
Positive_regulation (increase) of pMCAO
10) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2259310 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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