INT167311

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.77
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Aqp5) plasma membrane (Aqp5) transmembrane transport (Aqp5)
Anatomy Link Frequency
glands 3
taste receptor cells 2
acinar cells 1
Aqp5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 32 99.72 Very High Very High Very High
hyperexcitability 2 97.32 Very High Very High Very High
sodium channel 13 83.68 Quite High
agonist 58 78.28 Quite High
Calcium channel 2 76.80 Quite High
Central nervous system 6 76.64 Quite High
Neurotransmitter 2 74.16 Quite High
fibrosis 2 63.68 Quite High
corticosteroid 1 57.00 Quite High
Catecholamine 4 55.12 Quite High
Disease Link Frequency Relevance Heat
Aging 2 99.40 Very High Very High Very High
Ganglion Cysts 17 84.72 Quite High
Injury 39 80.40 Quite High
Disorders Of The Lacrimal System 6 78.44 Quite High
Neurological Disease 2 69.84 Quite High
Congenital Anomalies 3 65.84 Quite High
Pressure And Volume Under Development 39 65.68 Quite High
Hypoxia 12 64.32 Quite High
Cystic Fibrosis 1 63.68 Quite High
Adult Respiratory Distress Syndrome 92 62.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The salivary flow of the transplanted glands was significantly decreased, and the mRNA and protein levels of TRPV1 and aquaporin 5 (AQP5) were downregulated in the transplanted glands.
Gene_expression (levels) of aquaporin 5 in glands
1) Confidence 0.61 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20360133 Disease Relevance 0.08 Pain Relevance 0.54
The salivary flow of the transplanted glands was significantly decreased, and the mRNA and protein levels of TRPV1 and aquaporin 5 (AQP5) were downregulated in the transplanted glands.
Gene_expression (levels) of AQP5 in glands
2) Confidence 0.61 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20360133 Disease Relevance 0.08 Pain Relevance 0.54
The same study reported that the human Müller cell line MIO-M1 [11] expressed mRNA for AQP0, AQP1, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, and AQP11 but not AQP2, AQP6, and AQP12 [10].
Gene_expression (expressed) of AQP5
3) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.62 Pain Relevance 0
Preincubation of cells with PD98059, an inhibitor of ERK kinase, suppressed the capsaicin-induced mRNA expression of AQP5.
Gene_expression (expression) of AQP5 associated with qutenza
4) Confidence 0.47 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20360133 Disease Relevance 0.06 Pain Relevance 0.59
Topical capsaicin cream increased secretion and upregulated levels of TRPV1 and AQP5 in transplanted glands.
Gene_expression (levels) of AQP5 in glands associated with qutenza
5) Confidence 0.47 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20360133 Disease Relevance 0.07 Pain Relevance 0.58
Several types of aquaporins are expressed by taste receptor cells including AQP5, which is expressed on the apical membrane, and AQP1 and AQP2 which are expressed on the basolateral membrane (Gilbertson et al., 2006).
Gene_expression (expressed) of AQP5 in taste receptor cells
6) Confidence 0.44 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967336 Disease Relevance 0 Pain Relevance 0.11
Several types of aquaporins are expressed by taste receptor cells including AQP5, which is expressed on the apical membrane, and AQP1 and AQP2 which are expressed on the basolateral membrane (Gilbertson et al., 2006).
Gene_expression (expressed) of AQP5 in taste receptor cells
7) Confidence 0.44 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967336 Disease Relevance 0 Pain Relevance 0.11
In addition, the expression of several aquaporins including AQP1, AQP2, AQP3, and AQP5 decrease with aging [49–51], and therefore AQP4 expression may also decrease with aging.
Gene_expression (expression) of AQP5 associated with aging
8) Confidence 0.32 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.20 Pain Relevance 0.05
AQP5 is present in type I alveolar cells and in submucosal gland acinar cells.
Gene_expression (present) of AQP5 in acinar cells
9) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.67 Pain Relevance 0.23

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