INT167319

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.63
Pain Relevance 1.77

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peptidase activity (PCSK2) extracellular space (PCSK2) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)
Anatomy Link Frequency
lung 2
OPRM1 (Homo sapiens)
PCSK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 10 100.00 Very High Very High Very High
Opioid 12 97.96 Very High Very High Very High
Morphine 4 89.92 High High
Endogenous opioid 4 89.32 High High
Disease Link Frequency Relevance Heat
Lung Cancer 8 96.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue samples from patients with lung cancer were examined by immunohistochemistry to identify the components of the opioid network: beta-endorphin (END); its precursor, proopiomelanocortin (POMC); the key processing enzymes prohormone convertase 1 and 2; carboxypeptidase E; and END's corresponding opioid receptor, the mu-opioid receptor (MOR).
mu-opioid receptor Binding (opioid receptor) of prohormone convertase 1 and 2 in lung associated with lung cancer, opioid receptor and opioid
1) Confidence 0.22 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20360624 Disease Relevance 0.32 Pain Relevance 0.89
Tissue samples from patients with lung cancer were examined by immunohistochemistry to identify the components of the opioid network: beta-endorphin (END); its precursor, proopiomelanocortin (POMC); the key processing enzymes prohormone convertase 1 and 2; carboxypeptidase E; and END's corresponding opioid receptor, the mu-opioid receptor (MOR).
MOR Binding (opioid receptor) of prohormone convertase 1 and 2 in lung associated with lung cancer, opioid receptor and opioid
2) Confidence 0.22 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20360624 Disease Relevance 0.32 Pain Relevance 0.89

General Comments

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