INT16735

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 0.35
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 3
neuronal 2
nucleus accumbens 1
substantia nigra 1
projection neurons 1
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 462 100.00 Very High Very High Very High
agonist 107 100.00 Very High Very High Very High
gABA 95 100.00 Very High Very High Very High
nMDA receptor 9 100.00 Very High Very High Very High
Nucleus accumbens 10 99.84 Very High Very High Very High
Cannabinoid receptor 1 99.80 Very High Very High Very High
Substantia nigra 22 99.28 Very High Very High Very High
Pyramidal cell 5 98.84 Very High Very High Very High
Kappa opioid receptor 1 98.76 Very High Very High Very High
antagonist 62 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Morphine Dependence 2 96.16 Very High Very High Very High
Targeted Disruption 6 75.36 Quite High
Anxiety Disorder 5 55.00 Quite High
Shock 10 26.12 Quite Low
Disease 66 5.00 Very Low Very Low Very Low
Parkinson's Disease 63 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 9 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was done to provide pharmacologic evidence for the location of those striatal dopamine D-1 and D-2 receptors that participate in the regulation of local acetylcholine (ACh) release.
Localization (location) of dopamine D-1 associated with dopamine
1) Confidence 0.61 Published 1986 Journal Life Sci. Section Abstract Doc Link 2940432 Disease Relevance 0 Pain Relevance 0.38
The localization of D1 receptor patches corresponded to striosomes identified by TH-immunoreactive islands.
Localization (localization) of D1 receptor
2) Confidence 0.49 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1849802 Disease Relevance 0 Pain Relevance 0.23
The effects of CCK-4 on dopamine D1 agonist-induced grooming are blocked by a CCK(A) receptor antagonist: evidence for a novel CCK receptor subtype?
Localization (grooming) of dopamine D1 associated with dopamine, antagonist and agonist
3) Confidence 0.47 Published 1997 Journal Neuropharmacology Section Title Doc Link 9517439 Disease Relevance 0.06 Pain Relevance 0.95
This persistent neuroadaptive effect was not observed studying dopamine D1 receptor-mediated [(3)H]GABA release in nucleus accumbens slices.
Localization (release) of dopamine D1 receptor-mediated in nucleus accumbens associated with nucleus accumbens, gaba and dopamine
4) Confidence 0.45 Published 2001 Journal Synapse Section Abstract Doc Link 11574945 Disease Relevance 0 Pain Relevance 1.66
Synergistically interacting dopamine D1 and NMDA receptors mediate nonvesicular transporter-dependent GABA release from rat striatal medium spiny neurons.
Localization (release) of dopamine D1 in neurons associated with gaba, dopamine and nmda receptor
5) Confidence 0.34 Published 2000 Journal J. Neurosci. Section Title Doc Link 10777812 Disease Relevance 0 Pain Relevance 0.96
Sections from the substantia nigra were used for the autoradiographic localization of D1 dopamine and cannabinoid receptors.
Localization (localization) of D1 dopamine in substantia nigra associated with dopamine, cannabinoid receptor and substantia nigra
6) Confidence 0.32 Published 1994 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7621502 Disease Relevance 0 Pain Relevance 0.46
The dopaminergic suppression of synaptic transmission is therefore mediated by a D2 receptor-dependent reduction in transmitter release, and a D1 receptor-dependent increase in a K+ conductance.
Localization (release) of D1 receptor
7) Confidence 0.16 Published 2008 Journal Neural Plasticity Section Abstract Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.22
Phenotypical characterization of striatal neurons expressing mu and kappa opioid receptor mRNAs showed that, in striatonigral neurons, both mRNAs were colocalized with D1-receptor and Dyn mRNAs.
Localization (colocalized) of D1-receptor in neurons associated with kappa opioid receptor
8) Confidence 0.16 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10051749 Disease Relevance 0.15 Pain Relevance 1.50
These results suggest that, although colocalization of D1a and D2 receptors is limited, functional D1 and D2 class receptors are colocalized in nearly one-half of all medium spiny projection neurons.
Localization (colocalization) of D1a in projection neurons associated with projection neuron
9) Confidence 0.15 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815934 Disease Relevance 0 Pain Relevance 0.73
In the present study, D1 receptor immunoreactivity was mainly localized at the perikarya of layer V pyramidal cells and in nonpyramidal neurons of layer VI in the gerbil auditory cortex.
Localization (localized) of D1 receptor in neurons associated with pyramidal cell
10) Confidence 0.09 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.41
Postsynaptic D1-receptor localization has been suggested, on the basis of the detection of D1-receptor mRNA (Fremeau Jr. et al., 1991).
Localization (localization) of D1-receptor
11) Confidence 0.08 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.14
Interestingly, blockade of D1LRs in these studies resulted in increased spontaneous neuronal activity, suggesting that the D1LRs are occupied by endogenous dopamine under normal conditions (Kliem et al., 2007a).
Localization (blockade) of D1LRs in neuronal associated with dopamine
12) Confidence 0.07 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.08 Pain Relevance 0.35
Interestingly, blockade of D1LRs in these studies resulted in increased spontaneous neuronal activity, suggesting that the D1LRs are occupied by endogenous dopamine under normal conditions (Kliem et al., 2007a).
Localization (occupied) of D1LRs in neuronal associated with dopamine
13) Confidence 0.07 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.07 Pain Relevance 0.43

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