INT167373

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
PSC 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 98.00 Very High Very High Very High
alcohol 2 85.52 High High
metalloproteinase 14 79.20 Quite High
Osteoarthritis 31 67.76 Quite High
Inflammation 2 64.12 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 43 99.24 Very High Very High Very High
Primary Sclerosing Cholangitis 5 98.28 Very High Very High Very High
Pancreatitis 9 98.00 Very High Very High Very High
Sprains And Strains 21 92.04 High High
Disease 1 80.32 Quite High
Fibrosis 2 78.96 Quite High
Osteoarthritis 31 67.76 Quite High
Keloid Scars 1 64.68 Quite High
INFLAMMATION 2 64.12 Quite High
Necrosis 1 63.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.
Positive_regulation (increased) of Transcription (Expression) of collagen in PSC associated with primary sclerosing cholangitis and chronic pancreatitis
1) Confidence 0.12 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.32 Pain Relevance 0.72
Interestingly, in this study, DBA/1 mice maintained a high level of collagen type II neo-synthesis and a low collagen catabolic activity for 8 weeks after injury.
Positive_regulation (level) of Transcription (activity) of collagen associated with injury
2) Confidence 0.08 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.50 Pain Relevance 0.07

General Comments

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