INT167374

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.90
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
retina 1
thyroid 1
PSC 1
hyaloid vessels 1
lens 1
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 15 99.48 Very High Very High Very High
Chronic pancreatitis 8 95.44 Very High Very High Very High
alcohol 5 85.52 High High
Osteoarthritis 31 67.76 Quite High
Inflammation 25 64.12 Quite High
cytokine 9 55.12 Quite High
tolerance 12 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 70 99.24 Very High Very High Very High
Primary Sclerosing Cholangitis 5 97.28 Very High Very High Very High
Pancreatitis 9 95.44 Very High Very High Very High
Sprains And Strains 22 90.04 High High
Cataract 60 83.60 Quite High
Fibrosis 2 78.96 Quite High
Shock 45 75.32 Quite High
Disease 10 75.20 Quite High
Osteoarthritis 31 67.76 Quite High
Keloid Scars 1 64.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.
Transcription (Expression) of collagen in PSC associated with primary sclerosing cholangitis and chronic pancreatitis
1) Confidence 0.17 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.29 Pain Relevance 0.70
Interestingly, in this study, DBA/1 mice maintained a high level of collagen type II neo-synthesis and a low collagen catabolic activity for 8 weeks after injury.
Transcription (activity) of collagen associated with injury
2) Confidence 0.11 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.49 Pain Relevance 0.07
Although CIITA was initially described as a master regulator of MHC class II transcription, it is now clear that it can both activate and suppress transcription of several genes such as collagen (6), matrix metalloproteinase-9 (7), IL-4 (8), Fas ligand (9) and thyroid specific genes (10, 11).
Transcription (transcription) of collagen in thyroid associated with metalloproteinase
3) Confidence 0.06 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.12 Pain Relevance 0.08
1 (IV)-collagen mRNA has been detected in the lens, hyaloid vessels, and retina during ocular development (40).
Transcription (detected) of collagen in retina
4) Confidence 0.05 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.33 Pain Relevance 0
1 (IV)-collagen mRNA has been detected in the lens, hyaloid vessels, and retina during ocular development (40).
Transcription (detected) of collagen in lens
5) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.33 Pain Relevance 0
1 (IV)-collagen mRNA has been detected in the lens, hyaloid vessels, and retina during ocular development (40).
Transcription (detected) of collagen in hyaloid vessels
6) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.33 Pain Relevance 0

General Comments

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