INT167381

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.15
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DES) cytoskeleton (DES) intracellular (DES)
cytoskeleton organization (DES) cytoplasm (DES)
Anatomy Link Frequency
smooth muscle 1
PSC 1
DES (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 90.72 High High
Chronic pancreatitis 8 81.92 Quite High
Inflammation 3 69.32 Quite High
imagery 2 63.44 Quite High
Pain 2 45.08 Quite Low
ischemia 1 35.60 Quite Low
Angina 7 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Histiocytic Sarcoma 33 99.80 Very High Very High Very High
Primary Sclerosing Cholangitis 5 99.60 Very High Very High Very High
Osteogenic Sarcomas 5 99.18 Very High Very High Very High
Sarcoma 12 98.84 Very High Very High Very High
Restenosis 18 98.58 Very High Very High Very High
Melanoma 1 98.32 Very High Very High Very High
Carcinoma 3 98.10 Very High Very High Very High
Cancer 29 97.70 Very High Very High Very High
Malignant Neoplastic Disease 24 97.08 Very High Very High Very High
Thrombosis 21 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Localization (frequency) of desmin in PSC associated with primary sclerosing cholangitis
1) Confidence 0.73 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.28 Pain Relevance 0.69
Other tumors, such as carcinomas, melanomas, and soft tissue sarcomas, primary or metastatic, can be confused with HS and were excluded in our case by the lack of immunoreactivity for pancytokeratin, CAM 5.2, CK 903, TTF1, HMB45, MART-1/Melan A, CD99, CD117, smooth muscle actin, desmin, and myogenin.
Localization (excluded) of desmin in smooth muscle associated with sarcoma, melanoma, cancer, histiocytic sarcoma and carcinoma
2) Confidence 0.73 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.81 Pain Relevance 0.03
For example osteosarcoma exhibit strong positivity for Vimentin, variable for Actin/Desmin and S-100, if chondroid differentiation is present.
Localization (variable) of Desmin associated with osteogenic sarcomas
3) Confidence 0.73 Published 2007 Journal Cytojournal Section Body Doc Link PMC1872031 Disease Relevance 0.38 Pain Relevance 0.06
Drug-eluting stents are associated with excessive inhibition of vascular cell proliferation which may lead to rare but serious complications such as late incomplete stent apposition, aneurysm formation, and late or very late stent thrombosis due to impaired re-endothelialization.21,22 A ‘pro-healing’ approach for prevention of in-stent restenosis is intuitively favoured over the use of cytotoxic or cytostatic drugs released from a DES.
Localization (released) of DES associated with aneurism, restenosis and thrombosis
4) Confidence 0.06 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2862178 Disease Relevance 0.67 Pain Relevance 0

General Comments

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