INT167409

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.86
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 79 99.84 Very High Very High Very High
qutenza 12 94.72 High High
antagonist 1 43.76 Quite Low
imagery 15 27.64 Quite Low
headache 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 239 98.12 Very High Very High Very High
Cancer 120 97.52 Very High Very High Very High
Death 113 94.28 High High
Hypoxia 31 93.96 High High
Ovarian Cancer 8 84.28 Quite High
Malignant Neoplastic Disease 10 75.00 Quite High
Stress 4 75.00 Quite High
Capsule Opacification 45 72.80 Quite High
Cataract 19 67.88 Quite High
Cervical Cancer 20 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Understanding the molecular basis by which Akt gene expression is regulated will ultimately help us to design better strategies to treat cancer.
Regulation (regulated) of Gene_expression (expression) of Akt gene associated with cancer
1) Confidence 0.56 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.27 Pain Relevance 0
Western blotting analysis demonstrated that the levels of Akt protein and phosphorylated Akt were diminished by the treatment in the control cells, but not in the cells expressing the constitutively active Akt (Fig. 4B).
Regulation (were) of Gene_expression (levels) of Akt
2) Confidence 0.41 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.80 Pain Relevance 0
Since Akt is a key regulator of cellular survival, we studied the effects of HDAC inhibitors on Akt expression by using quantitative real-time RT-PCR analysis with specific primers and corresponding TaqMan probes for different Akt isoforms.
Regulation (effects) of Gene_expression (expression) of Akt
3) Confidence 0.41 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.66 Pain Relevance 0
Cells treated with AR-12 alone did not significantly alter pAkt expression (Figure 2A,).
Neg (not) Regulation (alter) of Gene_expression (expression) of pAkt
4) Confidence 0.36 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.21 Pain Relevance 0
Western blotting analysis demonstrated that the levels of Akt protein and phosphorylated Akt were diminished by the treatment in the control cells, but not in the cells expressing the constitutively active Akt (Fig. 4B).
Regulation (were) of Gene_expression (levels) of Akt
5) Confidence 0.36 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.80 Pain Relevance 0
In addition, pharmacological blockade or knockdown of the p38 gene down-regulated Akt activation and LC3II levels but did not affect ERK, and pharmacological blockade or knockdown of the ERK gene up-regulated LC3II induction by capsaicin.
Neg (not) Regulation (regulated) of Gene_expression (activation) of Akt associated with qutenza
6) Confidence 0.26 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.58 Pain Relevance 0.80
The expression levels of both MAPK and Akt remained unchanged by nicotine in all treatment groups.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of Akt associated with nicotine
7) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 1.24 Pain Relevance 0.43
Single-agent atRA also did not significantly affect AKT or MAPK expression or activity.
Neg (not) Regulation (affect) of Gene_expression (expression) of AKT
8) Confidence 0.09 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.32 Pain Relevance 0

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