INT167424

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.43
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pak1) Golgi apparatus (Pak1) plasma membrane (Pak1)
nucleus (Pak1) kinase activity (Pak1) cytoplasm (Pak1)
Anatomy Link Frequency
liver 1
Pak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 99.98 Very High Very High Very High
Inflammation 4 99.78 Very High Very High Very High
withdrawal 1 93.16 High High
Analgesic 1 90.40 High High
Paracetamol 9 89.52 High High
Inflammatory mediators 1 65.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.78 Very High Very High Very High
Necrosis 2 97.84 Very High Very High Very High
Cancer 2 97.48 Very High Very High Very High
Drug-induced Liver Injury 3 94.04 High High
Hepatotoxicity 3 92.16 High High
Acute Liver Failure 1 90.80 High High
Toxicity 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pro-inflammatory cytokines activate the mitogen activated protein kinase, c-Jun-N-terminal kinase (JNK) in the liver.
Positive_regulation (activate) of activated protein kinase in liver associated with inflammation and cytokine
1) Confidence 0.14 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.43 Pain Relevance 0.83

General Comments

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