INT167427

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 2.83
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mapk8, Tnf) mitochondrion (Mapk8) intracellular (Tnf)
extracellular matrix organization (Tnf) cytoplasm (Mapk8) cell proliferation (Tnf)
Anatomy Link Frequency
hepatocytes 4
Mapk8 (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 18 98.64 Very High Very High Very High
withdrawal 2 89.76 High High
Inflammation 8 86.60 High High
cytokine 6 86.08 High High
Analgesic 2 75.92 Quite High
Inflammatory mediators 2 63.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Toxicity 6 96.80 Very High Very High Very High
Drug-induced Liver Injury 6 95.52 Very High Very High Very High
Acute Liver Failure 2 92.48 High High
INFLAMMATION 10 86.60 High High
Hepatotoxicity 6 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
c-Jun N-terminal kinase Regulation (Role) of Regulation (regulating) of tumor necrosis factor-alpha in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
1) Confidence 0.26 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.42 Pain Relevance 0.85
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
JNK Regulation (Role) of Regulation (regulating) of tumor necrosis factor-alpha in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
2) Confidence 0.26 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.42 Pain Relevance 0.85

General Comments

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