INT167428

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.31
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
biosynthetic process (Gpt) cytoplasm (Gpt)
Il1b (Mus musculus)
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.32 Very High Very High Very High
Inflammatory mediators 1 88.64 High High
Inflammation 4 84.32 Quite High
Analgesic 1 75.52 Quite High
cytokine 3 68.52 Quite High
withdrawal 1 61.72 Quite High
Disease Link Frequency Relevance Heat
Toxicity 3 89.72 High High
INFLAMMATION 5 88.24 High High
Hepatotoxicity 3 85.72 High High
Cancer 2 75.00 Quite High
Necrosis 2 75.00 Quite High
Drug-induced Liver Injury 3 62.60 Quite High
Acute Liver Failure 1 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that, pre-treatment with TNF-alpha resulted in approximately 50 to 60% increase in alanine aminotransferase (ALT) levels by APAP or CPZ, while interleukin-1beta (IL-1beta) or IL6 treatments showed only 15-20% increase in ALT release.
IL-1beta Positive_regulation (increase) of Localization (release) of ALT associated with paracetamol
1) Confidence 0.43 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.31 Pain Relevance 1.11

General Comments

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