INT167429

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.11
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk8, RYBP) nucleus (Mapk8, RYBP) nucleoplasm (RYBP)
mitochondrion (Mapk8) intracellular (RYBP) DNA binding (RYBP)
Mapk8 (Mus musculus)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 9 100.00 Very High Very High Very High
cytokine 3 83.60 Quite High
Inflammatory mediators 1 79.76 Quite High
Inflammation 4 75.44 Quite High
Analgesic 1 66.64 Quite High
withdrawal 1 52.84 Quite High
Disease Link Frequency Relevance Heat
Toxicity 3 99.64 Very High Very High Very High
INFLAMMATION 5 79.36 Quite High
Hepatotoxicity 3 76.84 Quite High
Cancer 2 75.00 Quite High
Necrosis 2 75.00 Quite High
Drug-induced Liver Injury 3 53.72 Quite High
Acute Liver Failure 1 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The JNK inhibitor, SP600125 significantly diminished APAP and CPZ toxicity with or without TNF-alpha.
Negative_regulation (inhibitor) of JNK Negative_regulation (diminished) of APAP associated with toxicity and paracetamol
1) Confidence 0.01 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.11 Pain Relevance 1.09

General Comments

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