INT167440

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATM) signal transduction (ATM) cell death (ATM)
cytoplasmic membrane-bounded vesicle (ATM) nucleus (ATM) DNA binding (ATM)
Anatomy Link Frequency
lung 1
ATM (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 86.84 High High
cINOD 1 74.96 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Piles 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 99.18 Very High Very High Very High
Adenocarcinoma 1 98.42 Very High Very High Very High
Depression 1 86.84 High High
Cancer 30 78.24 Quite High
Stress 1 77.16 Quite High
INFLAMMATION 3 74.72 Quite High
Breast Cancer 1 50.92 Quite High
Toxicity 18 50.00 Quite Low
Squamous Cell Carcinoma 4 9.84 Low Low
Skin Cancer 4 8.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven genes (ATM, BAX, CCNA2, CDC27, RAD50 and p21) were prominently altered, and six (ATM, CCND2, CCNF, CDC20, CDK1A and RAD50) were commonly altered with both concentrations.
Regulation (altered) of ATM
1) Confidence 0.20 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372855 Disease Relevance 0.39 Pain Relevance 0.07
Experiments in A 549 lung adenocarcinoma and in K562 erythroblastoid leukaemia cells have shown that caffeine inhibits ATM and ATR kinases which control checkpoints via phosphorylation of p53 thereby maintaining the G2 block and controlling HR repair [21,24,32,48,51].
Regulation (control) of ATM in lung associated with adenocarcinoma and leukemia
2) Confidence 0.14 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.28 Pain Relevance 0.04

General Comments

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