INT167446

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 2.01
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNA2) mitosis (CCNA2) nucleus (CCNA2)
cell division (CCNA2) cytoplasm (CCNA2)
Anatomy Link Frequency
brains 2
neurons 1
microglia 1
CCNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 2044 99.82 Very High Very High Very High
Central nervous system 70 94.84 High High
cINOD 1 74.56 Quite High
local anesthetic 7 70.56 Quite High
sodium channel 7 56.56 Quite High
Dopamine 7 49.28 Quite Low
monoamine 21 5.00 Very Low Very Low Very Low
cerebral cortex 14 5.00 Very Low Very Low Very Low
Neurotransmitter 14 5.00 Very Low Very Low Very Low
Neurobehavioral 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 190 96.92 Very High Very High Very High
Repression 7 83.88 Quite High
Hyperoxia 7 79.80 Quite High
Cancer 4 77.84 Quite High
INFLAMMATION 1 74.32 Quite High
Hyperplasia 7 73.52 Quite High
Gliosis 7 69.56 Quite High
Death 57 66.36 Quite High
Breast Cancer 1 50.52 Quite High
Toxicity 28 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Screening of molecules that can regulate the promoter activity of cyclin A2 demonstrated that ATF4 is specifically up-regulated by cocaine exposure; this effect of cocaine occurs 3 h prior to cyclin A2 down-regulation.
Regulation (regulate) of cyclin A2 associated with cocaine
1) Confidence 0.39 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.58 Pain Relevance 0.40
Cocaine causes specific down-regulation of cyclin A2 in AF5 cells, primary neural and A2B5+ progenitor cells, and fetal brains exposed to cocaine in utero.
Regulation (regulation) of cyclin A2 in brains associated with cocaine
2) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.18 Pain Relevance 0.62
Finally, treatment of pregnant rats with cimetidine (which inhibits the action of cytochrome P450) counteracted both the inhibition of neural progenitor cell proliferation and the cyclin A2 down-regulation that cocaine exposure induced in the brains of their unborn pups.


Regulation (regulation) of cyclin A2 in brains associated with cocaine
3) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.35
These data suggest that the p53-p21 pathway may be involved in longer-term effects of cocaine, but not in the short-term action of cocaine that promotes down-regulation of cyclin A2 within 24 h.
Regulation (regulation) of cyclin A2 associated with cocaine
4) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.31 Pain Relevance 0.63
Seven genes (ATM, BAX, CCNA2, CDC27, RAD50 and p21) were prominently altered, and six (ATM, CCND2, CCNF, CDC20, CDK1A and RAD50) were commonly altered with both concentrations.
Regulation (altered) of CCNA2
5) Confidence 0.19 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372855 Disease Relevance 0.39 Pain Relevance 0.07
Treatment of AF5 cells with a cyclin A2 expression vector (a piece of DNA that directs the production of cyclin A2) counteracted the down-regulation of cyclin A2 and restored AF5 proliferation in the presence of cocaine.
Regulation (regulation) of cyclin A2 associated with cocaine
6) Confidence 0.17 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.34
Cocaine-induced cyclin A2 down-regulation was observed in human neural progenitor and A2B5+ progenitor cells, but not in human neurons and microglia.
Regulation (regulation) of cyclin A2 in microglia associated with cocaine
7) Confidence 0.17 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.28 Pain Relevance 0.53
Cocaine-induced cyclin A2 down-regulation was observed in human neural progenitor and A2B5+ progenitor cells, but not in human neurons and microglia.
Regulation (regulation) of cyclin A2 in neurons associated with cocaine
8) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.28 Pain Relevance 0.53

General Comments

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