INT167457

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 10
Disease Relevance 2.27
Pain Relevance 5.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Anatomy Link Frequency
cortex 5
adult brain 4
brain 4
Pet1 2
dorsal 1
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 20 100.00 Very High Very High Very High
Serotonin 18 100.00 Very High Very High Very High
monoamine 16 100.00 Very High Very High Very High
amygdala 12 100.00 Very High Very High Very High
fluoxetine 20 99.98 Very High Very High Very High
Dopamine 48 99.32 Very High Very High Very High
Neurotransmitter 12 96.68 Very High Very High Very High
Raphe 96 87.84 High High
tricyclic antidepressant 20 87.40 High High
sSRI 16 85.24 High High
Disease Link Frequency Relevance Heat
Depression 38 83.72 Quite High
Body Weight 18 81.32 Quite High
Congenital Anomalies 6 68.04 Quite High
Targeted Disruption 12 57.16 Quite High
Mental Disorders 18 51.92 Quite High
Post-traumatic Stress Disorder 6 48.64 Quite Low
Anxiety Disorder 10 22.56 Low Low
Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, these results indicate that deleting Lmx1b in the adult brain impairs Tph2 expression, leading to a deficiency of central 5-HT.
Negative_regulation (impairs) of Gene_expression (expression) of Tph2 in adult brain
1) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
Loss of Pet1 in the 5-HTergic neurons leads to a decrease of Tph2 expression but no change in Lmx1b expression.
Negative_regulation (decrease) of Gene_expression (expression) of Tph2 in Pet1
2) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.05 Pain Relevance 0.13
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of Gene_expression (pression. ) of TPH2 in cortex associated with locus ceruleus, amygdala and fluoxetine
3) Confidence 0.42 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.24
After administration of tamoxifen, the level of 5-HT in the brain of Lmx1b iCKO mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (Tph2), serotonin transporter (Sert) and vesicular monoamine transporter 2 (Vmat2) was greatly down-regulated.
Negative_regulation (down) of Gene_expression (expression) of Tph2 in brain associated with serotonin and monoamine
4) Confidence 0.42 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.27
After administration of tamoxifen, the level of 5-HT in the brain of Lmx1b iCKO mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (Tph2), serotonin transporter (Sert) and vesicular monoamine transporter 2 (Vmat2) was greatly down-regulated.
Negative_regulation (regulated) of Gene_expression (expression) of Tph2 in brain associated with serotonin and monoamine
5) Confidence 0.42 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.27
Nevertheless, these results indicate that deleting Lmx1b in the adult brain impairs Tph2 expression, leading to a deficiency of central 5-HT.
Negative_regulation (deleting) of Gene_expression (expression) of Tph2 in adult brain
6) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
In situ hybridization probes against Tph2, Sert, Aadc and Dopamine ?
Negative_regulation (hybridization) of Gene_expression (probes) of Tph2 associated with dopamine
7) Confidence 0.36 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.21 Pain Relevance 0.05
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of in locus coeruleus Gene_expression (pression. ) of TPH2 in cortex associated with locus ceruleus, amygdala and fluoxetine
8) Confidence 0.14 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.24
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of in dorsal Gene_expression (pression. ) of TPH2 in cortex associated with locus ceruleus, amygdala and fluoxetine
9) Confidence 0.14 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.24
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Negative_regulation (decreased) of in amygdala Gene_expression (pression. ) of TPH2 in cortex associated with locus ceruleus, amygdala and fluoxetine
10) Confidence 0.14 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.24

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