INT167468

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.08
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
eyes 4
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 46 100.00 Very High Very High Very High
antidepressant 1 86.80 High High
chemokine 3 51.20 Quite High
cytokine 2 50.24 Quite High
COX-2 inhibitor 26 48.96 Quite Low
Inflammation 25 26.08 Quite Low
Pain 13 10.00 Low Low
nociceptor 2 10.00 Low Low
Dextromethorphan 30 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 82.24 Quite High
Keratitis 4 50.00 Quite Low
Herpes Simplex Virus 4 50.00 Quite Low
Leukemia 2 47.68 Quite Low
Cold Sores 2 45.32 Quite Low
Disease 9 26.44 Quite Low
INFLAMMATION 29 26.08 Quite Low
Cancer 38 25.40 Quite Low
Solid Tumor 1 16.48 Low Low
Skin Cancer 5 8.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: In eyes that had had HSV keratitis, corneal sensitivity to mechanical forces and heat was significantly impaired, suggesting that axonal damage and/or altered expression of membrane ion channels involved in transduction and membrane excitability affects primarily the mechano- and polymodal nociceptor terminals.
Regulation (altered) of Gene_expression (expression) of membrane in eyes
1) Confidence 0.52 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 20375335 Disease Relevance 0 Pain Relevance 0
Analysis of 27-hydroxylase and ABCA1 message by QRT-PCR
Regulation (Analysis) of Gene_expression (message) of ABCA1
2) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.08 Pain Relevance 0
We therefore examined the effect of non-selective and selective COX-1 inhibitors on 27-hydroxylase and ABCA1 expression.


Spec (examined) Regulation (effect) of Gene_expression (expression) of ABCA1
3) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: In eyes that had had HSV keratitis, corneal sensitivity to mechanical forces and heat was significantly impaired, suggesting that axonal damage and/or altered expression of membrane ion channels involved in transduction and membrane excitability affects primarily the mechano- and polymodal nociceptor terminals.
Regulation (affects) of Gene_expression (expression) of membrane in eyes
4) Confidence 0.23 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 20375335 Disease Relevance 0 Pain Relevance 0
CYP2D6 is a peripheral membrane-bound protein and is one of the most important CYPs in humans, being involved in the metabolism of about 30% of the currently marketed drugs, including ?
Regulation (peripheral) of Gene_expression (protein) of membrane-bound
5) Confidence 0.03 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0.04
Expression of membrane-bound MMPs is differentially controlled at the transcriptional level [63, 65, 66].
Regulation (controlled) of Gene_expression (Expression) of membrane associated with metalloproteinase
6) Confidence 0.01 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0 Pain Relevance 0.39

General Comments

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