| Several independent studies have reinforced the crucial role of the brainstem in migraine resulting in primary dysfunction of the endogenous antinociceptive systems, including the periaqueductal grey and the dorsal raphe nucleus (DRN) in the midbrain as well as areas involved in the neuronal regulation of cerebral blood flow (DRN and locus coeruleus).
| Regulation (regulation) of DRN in raphe nucleus associated with medulla, locus ceruleus, periaqueductal grey, migraine, midbrain, raphe and antinociceptive
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