INT167477

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.04 Pain Relevance 1.12

nuclear envelope (TREX1) cell death (TREX1) nucleus (TREX1)

Anatomy Link Frequency raphe nucleus 1 TREX1 (Homo sapiens)

Pain Link Frequency Relevance Heat Locus ceruleus 1 99.80 midbrain 1 99.14 Raphe 1 98.54 Periaqueductal grey 1 98.12 Antinociceptive 1 97.26 Migraine 3 95.92 medulla 1 95.68 Cluster headache 2 89.52 imagery 1 82.92 headache 5 81.76

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1 98.12 Headache 7 95.92 Cluster Headache 2 89.52 Syndrome 2 86.80 Pain 1 80.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several independent studies have reinforced the crucial role of the brainstem in migraine resulting in primary dysfunction of the endogenous antinociceptive systems, including the periaqueductal grey and the dorsal raphe nucleus (DRN) in the midbrain as well as areas involved in the neuronal regulation of cerebral blood flow (DRN and locus coeruleus).

Regulation (regulation) of DRN in raphe nucleus associated with medulla, locus ceruleus, periaqueductal grey, migraine, midbrain, raphe and antinociceptive

1) Confidence 0.24 Published 2010 Journal Schmerz Section Abstract Doc Link 20376601 Disease Relevance 1.04 Pain Relevance 1.12

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