INT167484

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GGNBP2) signal transduction (CHRNE) transport (CHRNE)
cytoplasmic membrane-bounded vesicle (GGNBP2) nucleus (GGNBP2) plasma membrane (CHRNE)
CHRNE (Homo sapiens)
GGNBP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
antagonist 4 98.28 Very High Very High Very High
Pain 2 82.24 Quite High
depression 2 80.40 Quite High
Potency 2 71.52 Quite High
Disease Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This specificity is based on a larger number of hydrogen bonds between the carbamate group (another pharmacophore) of JN403 and the halpha7 sites, the electrostatic repulsion between the positively charged residues around the halpha3beta4 sites and the cationic center of JN403, fewer hydrogen bonds for the interaction of JN403 with the halpha3beta4 AChR, and an unfavorable van der Waals interaction between JN403 and the alpha4-beta2 interface.
AChR Binding (interaction) of JN403
1) Confidence 0.02 Published 2010 Journal Biochemistry Section Abstract Doc Link 20377277 Disease Relevance 0 Pain Relevance 0.29
The interaction of the agonist JN403 with the human (h) alpha7 nicotinic acetylcholine receptor (AChR) was compared to that for the competitive antagonist methyllycaconitine (MLA).
AChR Binding (interaction) of JN403 associated with antagonist and agonist
2) Confidence 0.02 Published 2010 Journal Biochemistry Section Abstract Doc Link 20377277 Disease Relevance 0 Pain Relevance 0.21

General Comments

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