INT167505

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (CXCL11) cytoplasm (CXCR3) signal transducer activity (CXCR3)
extracellular space (CXCL11) signal transduction (CXCL11) extracellular region (CXCL11)
Anatomy Link Frequency
T-cell 1
CXCR3 (Homo sapiens)
CXCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 100.00 Very High Very High Very High
chemokine 9 99.96 Very High Very High Very High
cytokine 9 93.88 High High
agonist 2 85.36 High High
cINOD 2 75.12 Quite High
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
diclofenac 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Pulmonary Sarcoidosis 2 98.40 Very High Very High Very High
Sarcoidosis 40 90.44 High High
Autoimmune Disease 1 61.36 Quite High
Granuloma 1 44.00 Quite Low
Disease 9 42.88 Quite Low
Syndrome 19 5.00 Very Low Very Low Very Low
Nicotine Addiction 16 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The chemokine receptor CXCR3 is expressed mainly on activated T lymphocytes and binds three pro-inflammatory, interferon-gamma-inducible chemokines: monokine induced by IFN-gamma (Mig/CXCL9), IFN-gamma-induced protein-10 (IP-10/CXCL10) and IFN-gamma-inducible T-cell alpha-chemoattractant (I-TAC/CXCL11).
CXCR3 Binding (binds) of interferon-gamma-inducible in T-cell associated with chemokine and inflammation
1) Confidence 0.26 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20379873 Disease Relevance 0.41 Pain Relevance 0.51
Further more, it has been shown that CXCR3 ligands, that is the M1 markers CXCL9, CXCL10 and CXCL11, seem essential in the pathogenesis of pulmonary sarcoidosis [6,7].
CXCR3 Binding (ligands) of CXCL11 associated with pulmonary sarcoidosis
2) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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