INT167546

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.78
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
epithelial cells 2
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 7 100.00 Very High Very High Very High
Cannabinoid receptor 2 99.84 Very High Very High Very High
Neuropathic pain 3 99.58 Very High Very High Very High
Spinal cord 2 96.56 Very High Very High Very High
fibrosis 6 93.84 High High
ischemia 49 78.52 Quite High
agonist 131 77.68 Quite High
Inflammation 116 77.68 Quite High
cytokine 10 76.00 Quite High
Cannabinoid 2 69.52 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 99.58 Very High Very High Very High
Cancer 444 98.16 Very High Very High Very High
Targeted Disruption 4 98.12 Very High Very High Very High
Chronic Lymphoid Leukemia 21 97.92 Very High Very High Very High
Bacterial Respiratory Disease 1 94.96 High High
Fibrosis 6 93.84 High High
Necrosis 11 93.32 High High
Hematologic Neoplasms 117 93.04 High High
Leukemia 36 92.44 High High
Myeloid Leukemia 15 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BM transplantation revealed that IQGAP1 expressed in both BM-derived cells and tissue resident cells, such as ECs, is required for post-ischemic neovascularization.
Positive_regulation (required) of Gene_expression (expressed) of ECs
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955540 Disease Relevance 0.55 Pain Relevance 0.11
In ECs and epithelial cells the TLR2 expression is low [27], but can be upregulated [43].
Positive_regulation (upregulated) of Gene_expression (expression) of ECs in epithelial cells
2) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.86 Pain Relevance 0.08
Models of neuropathic pain are associated with elevated spinal levels of endocannabinoids (ECs) and altered expression of cannabinoid receptors on primary sensory afferents and post-synaptic cells in the spinal cord.
Positive_regulation (elevated) of Gene_expression (expression) of ECs in spinal cord associated with endocannabinoid, cannabinoid receptor, neuropathic pain and spinal cord
3) Confidence 0.05 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20384778 Disease Relevance 0.41 Pain Relevance 0.62
Increased vascularity leads to elevated production of hematopoietic growth factors by new vessel ECs, which stimulates expression of VEGF and VEGFRs by CLL cells for autocrine signaling to promote survival [113, 170].
Positive_regulation (elevated) of Gene_expression (production) of ECs associated with chronic lymphoid leukemia
4) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.47 Pain Relevance 0.04
Increased vascularity leads to elevated production of hematopoietic growth factors by new vessel ECs, which stimulates expression of VEGF and VEGFRs by CLL cells for autocrine signaling to promote survival [113, 170].
Positive_regulation (leads) of Gene_expression (production) of ECs associated with chronic lymphoid leukemia
5) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.48 Pain Relevance 0.04
ligands upregulate expression and release of PAI-1 from ECs [193], which would inhibit degradation of tumor-associated fibrin leading to EC migration, proliferation, and angiogenesis [231].
Positive_regulation (upregulate) of Gene_expression (expression) of ECs associated with cancer
6) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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