INT167556

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.57
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MECP2) DNA binding (MECP2)
MECP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 120 99.58 Very High Very High Very High
alcohol 60 99.36 Very High Very High Very High
opiate 64 95.56 Very High Very High Very High
mu opioid receptor 8 91.68 High High
Nicotine 52 90.88 High High
Glutamate 12 84.80 Quite High
Dopamine 32 84.28 Quite High
opioid receptor 1 75.00 Quite High
cytokine 12 66.16 Quite High
Morphine 1 54.44 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 36 99.62 Very High Very High Very High
Alcohol Addiction 36 99.58 Very High Very High Very High
Myopia 80 99.56 Very High Very High Very High
Schizophrenia 156 99.34 Very High Very High Very High
Post-traumatic Stress Disorder 72 97.88 Very High Very High Very High
Opiate Addiction 52 95.32 Very High Very High Very High
Traumatic Stress Disorders 8 94.08 High High
Nicotine Addiction 44 90.88 High High
Disease 32 90.24 High High
Cirrhosis 7 71.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ChIP assays performed in the same setting showed that MeCP2 was highly recruited at the PPARG promoter in basal conditions and depleted after treatment with AZA or TSA alone or in combination (Figure 4, panel C).
MeCP2 Binding (depleted) of
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.25 Pain Relevance 0
The reduction of LTR expression is possibly explained by the binding of methyl-CpG-binding protein 1 complex and methyl-CpG-binding protein 2 to methylated Sp1 transcription factor binding sites, thereby inhibiting the binding of Sp1 transcription factors [282,283].
methyl-CpG-binding protein 2 Binding (binding) of
2) Confidence 0.13 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.17 Pain Relevance 0.09
In vitro DNA CpG-methylation of the promoter partially blocked binding of the Sp1 factor but induced MeCP2 binding.
MeCP2 Binding (binding) of
3) Confidence 0.08 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20385708 Disease Relevance 0.06 Pain Relevance 0.36
In other words, the association of rs235858 with high myopia gave the lowest p values on its own under all three genetic models.
rs235858 Binding (association) of associated with myopia
4) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.21 Pain Relevance 0
Alcohol dependence was not found to be associated with rs9370822 at the genotype level or under any inheritance model.
rs9370822 Binding (associated) of associated with addiction and alcohol
5) Confidence 0.00 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 1.25 Pain Relevance 0.96
However, the associations are unlikely to occur by chance due to sample size as five separate groups were analysed (including schizophrenia in a previous study) and four have been found to be significantly associated with rs9370822.
rs9370822 Binding (associated) of associated with schizophrenia
6) Confidence 0.00 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.67 Pain Relevance 0.42
Our schizophrenia study was the first to identify rs9370822 to be associated with a psychiatric condition [24].
rs9370822 Binding (associated) of associated with schizophrenia
7) Confidence 0.00 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.99 Pain Relevance 0.36
To investigate the importance of this SNP in the function of DTNBP1, a number of psychiatric conditions including addictive behaviours and anxiety disorders were analysed for association with rs9370822.


rs9370822 Spec (analysed) Binding (association) of associated with anxiety disorder
8) Confidence 0.00 Published 2010 Journal Behav Brain Funct Section Abstract Doc Link PMC2911395 Disease Relevance 0.96 Pain Relevance 0.41

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