INT16756

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Context Info
Confidence 0.39
First Reported 1989
Last Reported 1998
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.08
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 6
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 1 80.96 Quite High
dexamethasone 2 77.04 Quite High
antagonist 3 70.96 Quite High
Calcium channel 1 42.48 Quite Low
Catecholamine 1 26.96 Quite Low
Opioid 3 25.44 Quite Low
Enkephalin 7 25.00 Low Low
noradrenaline 1 25.00 Low Low
medulla 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 2 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of proenkephalin A (ProEnk A) mRNA and phenylethanolamine N-methyltransferase (PNMT) mRNA in response to cAMP analogues, forskolin and phorbol esters was examined in cultures of bovine adrenal chromaffin cells.
Regulation (response) of Spec (examined) Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
1) Confidence 0.39 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1850068 Disease Relevance 0.08 Pain Relevance 0
The effects of histamine on the regulation of proenkephalin A (ProEnk A) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression were examined in cultures of bovine adrenal chromaffin cells.
Regulation (regulation) of Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
2) Confidence 0.30 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767138 Disease Relevance 0 Pain Relevance 0.07
The effects of glucocorticoids on the expression of phenylethanolamine N-methyltransferase (PNMT) mRNA and proenkephalin A (ProEnk A) mRNA in cultures of bovine adrenal chromaffin cells were examined.
Spec (examined) Regulation (effects) of Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
3) Confidence 0.17 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767137 Disease Relevance 0 Pain Relevance 0.11
We have demonstrated that there are differential changes in the levels of tyrosine hydroxylase (TH), phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (Pro Enk A) mRNA in the fetal sheep adrenal during late gestation.
Regulation (changes) of Transcription (levels) of phenylethanolamine N-methyltransferase
4) Confidence 0.12 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648889 Disease Relevance 0 Pain Relevance 0

General Comments

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