INT167584

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Context Info
Confidence 0.83
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 94.84 High High
Hyperalgesia 1 88.72 High High
Bioavailability 3 71.56 Quite High
cytokine 1 53.16 Quite High
Multiple sclerosis 1 50.04 Quite High
Arthritis 1 49.08 Quite Low
aspirin 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 33 100.00 Very High Very High Very High
Hypertriglyceridemia 12 97.94 Very High Very High Very High
INFLAMMATION 9 94.84 High High
Hyperalgesia 1 88.72 High High
Diabetes Mellitus 10 79.00 Quite High
Metabolic Syndrome 8 78.52 Quite High
Obesity 5 65.76 Quite High
Disease 1 57.08 Quite High
Demyelinating Disease 1 50.04 Quite High
Dyslipidemia /

Combined Dyslipidemia

14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, a close pharmacokinetic/pharmacodynamic relationship was observed, which suggests that LPA is rapidly formed and degraded in vivo.
Protein_catabolism (degraded) of LPA
1) Confidence 0.83 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.67 Pain Relevance 0.46
In millimolar concentrations, niacin was shown to inhibit TG formation in HepG2 cells by diacylglycerol acyltransferase 2 inhibition and concomitantly to increase apolipoprotein B degradation (Jin et al 1991).
Protein_catabolism (degradation) of apolipoprotein associated with hypertriglyceridemia and disorder of lipid metabolism
2) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 1.09 Pain Relevance 0

General Comments

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