INT167585

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.19
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENPP2) extracellular region (ENPP2) plasma membrane (ENPP2)
transcription factor binding (ENPP2)
Anatomy Link Frequency
blood 3
plasma 1
ENPP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 99.52 Very High Very High Very High
Inflammation 48 99.40 Very High Very High Very High
Bioavailability 6 99.06 Very High Very High Very High
Hyperalgesia 6 98.16 Very High Very High Very High
Multiple sclerosis 7 96.40 Very High Very High Very High
Arthritis 6 95.44 Very High Very High Very High
adenocard 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 99.40 Very High Very High Very High
Hyperalgesia 6 98.16 Very High Very High Very High
Disease 6 97.80 Very High Very High Very High
Cancer 10 97.24 Very High Very High Very High
Demyelinating Disease 7 96.40 Very High Very High Very High
Arthritis 6 95.44 Very High Very High Very High
Metastasis 1 95.04 Very High Very High Very High
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel point mutations attenuate autotaxin activity

Background

Negative_regulation (attenuate) of autotaxin
1) Confidence 0.36 Published 2009 Journal Lipids Health Dis Section Title Doc Link PMC2649126 Disease Relevance 0.19 Pain Relevance 0
Inhibition of plasma autotaxin activity correlated with inhibition of autotaxin at the site of inflammation and in ex vivo whole blood.
Negative_regulation (inhibition) of autotaxin in blood associated with inflammation
2) Confidence 0.11 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.89 Pain Relevance 0.54
Inhibition of plasma autotaxin activity correlated with inhibition of autotaxin at the site of inflammation and in ex vivo whole blood.
Negative_regulation (Inhibition) of autotaxin in blood associated with inflammation
3) Confidence 0.11 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.91 Pain Relevance 0.55
Inhibition of autotaxin may have anti-inflammatory properties in a variety of diseases; however, this hypothesis has not been tested pharmacologically because of the lack of potent inhibitors.
Negative_regulation (Inhibition) of autotaxin associated with inflammation and disease
4) Confidence 0.11 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.71 Pain Relevance 0.34
PF-8380 has adequate oral bioavailability and exposures required for in vivo testing of autotaxin inhibition.
Negative_regulation (inhibition) of autotaxin associated with bioavailability
5) Confidence 0.08 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.92 Pain Relevance 0.50
Here, we report the development of a potent autotaxin inhibitor, PF-8380 [6-(3-(piperazin-1-yl)propanoyl)benzo[d]oxazol-2(3H)-one] with an IC(50) of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
Negative_regulation (inhibitor) of autotaxin in blood
6) Confidence 0.08 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.84 Pain Relevance 0.44
A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation.
Negative_regulation (inhibitor) of autotaxin in plasma associated with inflammation
7) Confidence 0.07 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 20392816 Disease Relevance 0.73 Pain Relevance 0.35

General Comments

This test has worked.

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