INT167586

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENPP2) extracellular region (ENPP2) plasma membrane (ENPP2)
transcription factor binding (ENPP2)
ENPP2 (Homo sapiens)
ENPP2 - H434Q (1) ENPP2 - H226Q (1)
Pain Link Frequency Relevance Heat
Inflammation 8 95.24 Very High Very High Very High
Arthritis 1 92.76 High High
Multiple sclerosis 3 92.16 High High
cytokine 1 77.28 Quite High
Bioavailability 1 41.04 Quite Low
Hyperalgesia 1 25.00 Low Low
adenocard 4 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 95.24 Very High Very High Very High
Cancer 9 93.08 High High
Arthritis 1 92.76 High High
Demyelinating Disease 3 92.16 High High
Disease 1 69.44 Quite High
Hyperalgesia 1 25.00 Low Low
Metastasis 2 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To better understand the altered hydrolytic efficiency and substrate selectivity of H226Q-ATX and H434Q-ATX, we determined the effects of substrate concentrations on the reaction rates and calculated the kinetic parameters Km and Vmax for each substrate.
Regulation (altered) of H434Q-ATX (H434Q)
1) Confidence 0.20 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
To better understand the altered hydrolytic efficiency and substrate selectivity of H226Q-ATX and H434Q-ATX, we determined the effects of substrate concentrations on the reaction rates and calculated the kinetic parameters Km and Vmax for each substrate.
Regulation (altered) of H226Q-ATX (H226Q)
2) Confidence 0.20 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but not limited to cancer, arthritis, and multiple sclerosis.
Regulation (responsible) of Autotaxin associated with multiple sclerosis, inflammation, cancer and arthritis
3) Confidence 0.09 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.59 Pain Relevance 0.25

General Comments

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