INT167588

Context Info Confidence 0.65 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.24 Pain Relevance 0.90

pigmentation (HPS1) cytoplasmic membrane-bounded vesicle (HPS1) lysosome (HPS1) cytoplasm (HPS1)

HPS1 (Homo sapiens)

Pain Link Frequency Relevance Heat reflex sympathetic dystrophy 2 100.00 Catechol-O-methyltransferase 109 98.84 Pain 23 97.28 alcohol 65 91.60 tolerance 1 86.68 addiction 11 81.60 Inflammation 1 27.48 Catecholamine 7 25.44 drug abuse 9 5.00 cocaine 3 5.00

Disease Link Frequency Relevance Heat Hantavirus Infection 78 100.00 Complex Regional Pain Syndromes 4 100.00 Pain 21 97.28 Poisoning 1 85.12 Alcohol Addiction 2 81.60 Schizophrenia 5 74.04 Aggression 1 73.32 Temporomandibular Joint Disorders 5 40.64 Hyperhomocysteinemia 2 31.16 Nutritional Deficiencies 1 29.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Despite the limitations, these findings indicate a need to educate HPs and students regarding substance use and abuse.

Localization (educate) of HPs

1) Confidence 0.65 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2265282 Disease Relevance 0.17 Pain Relevance 0.35

Individuals exhibiting both the highest and lowest COMT activity were homozygous for the val158 allele, which is present in both the LPS and HPS haplotypes.

Localization (present) of HPS associated with catechol-o-methyltransferase and hantavirus infection

2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.55 Pain Relevance 0.20

OBJECTIVES: Although the etiology of complex regional pain syndrome type 1 (CRPS 1) is still debated, many arguments favor central maladaptive changes in pain processing as an important causative factor.

Localization (etiology) of complex regional pain syndrome type 1 associated with complex regional pain syndromes, pain and reflex sympathetic dystrophy

3) Confidence 0.05 Published 2010 Journal Clin J Pain Section Abstract Doc Link 20393270 Disease Relevance 0.52 Pain Relevance 0.35

General Comments

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